Unanticipated toxicities from anticancer therapies: Survivors' perspectives
Unanticipated toxicities from anticancer therapies: Survivors' perspectives
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DOI：
10.1007/s00520-009-0769-1
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发表时间：
2010-11-01
影响因子：
3.1
通讯作者：
Lacouture, Mario E.
中科院分区：
文献类型：
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作者：
Gandhi, Mona;Oishi, Karen;Lacouture, Mario E.
肿瘤学治疗方法的改进提高了许多恶性肿瘤的生存率，将注意力转移到癌症的其他方面。特别是，治疗相关毒性的影响已获得相当大的关注，由于其身体和心理社会影响，并可能对临床结果的影响。这些不良事件还没有从幸存者的角度进行研究。目的从癌症幸存者的角度识别和描述对生活质量有负面影响的治疗相关毒性。设计定量研究，使用书面问卷和内容分析。在美国各地设置癌症幸存者研讨会。参与者来自六个幸存者组的共379名参与者：乳腺癌（n=250）、卵巢癌（n=27）、肺癌（n=23）、结肠直肠癌（n=15）、泌尿生殖系统癌（n=23）和其他癌症（n=45）。结果测量幸存者对治疗相关的皮肤、胃肠道和全身毒性的看法。在接受癌症治疗后。这些事件对他们的生活产生了负面影响。虽然胃肠道和宪法毒性也有负面影响，他们的发展是不变的关注之前和之后treatment.Conclusion皮肤毒性的影响是不可预见的癌症治疗前。由于这些事件对幸存者的生活产生负面影响，因此治疗前咨询和有效的干预措施至关重要，以最大限度地提高生活质量，并尽量减少不必要的治疗中断或中止。
Context Improved therapies in oncology have resulted in increased survival across numerous malignancies, shifting attention to other aspects of the cancer experience. In particular, the impact of treatment-related toxicities has gained considerable attention, due to their physical and psychosocial effects, and possible impact on clinical outcome. These untoward events have not been examined from the survivors' perspective.Objective To identify and describe treatment-related toxicities having a negative effect on quality of life from the perspective of cancer survivors.Design Quantitative study using written questionnaires and content analysis.Setting Cancer survivors' workshop across the United States.Participants A total of 379 participants from six survivor groups: breast (n=250), ovarian (n=27), lung (n=23), colorectal (n=15), genitourinary (n=23), and other cancers (n=45).Outcome measures Survivors' perceptions on treatment-related dermatologic, gastrointestinal, and constitutional toxicities.Results Survivors reported an increased concern regarding dermatologic toxicities, including irritated and dry skin, after receiving their cancer treatment. These events had a negative effect on their lives. Although gastrointestinal and constitutional toxicities also had a negative effect, the concern over their development was unchanged prior to and after treatments.Conclusion The impact of dermatologic toxicities is unanticipated prior to cancer treatments. Since these events have a negative effect on survivors' lives, pretreatment counseling and effective interventions are vital in order to maximize quality of life and minimize unnecessary treatment interruptions or discontinuations.