Cerebellar and premotor function in bimanual coordination: parametric neural responses to spatiotemporal complexity and cycling frequency
Cerebellar and premotor function in bimanual coordination: parametric neural responses to spatiotemporal complexity and cycling frequency
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DOI：
10.1016/j.neuroimage.2003.12.011
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发表时间：
2004-04-01
期刊：
影响因子：
5.7
通讯作者：
Swinnen, SP
中科院分区：
文献类型：
--
作者：
Debaere, F;Wenderoth, N;Swinnen, SP
在当前的功能磁共振成像（fMRI）研究中，我们评估了在时空复杂性和循环频率操作过程中控制双手协调的神经网络。应用参数分析来确定每个因素的影响以及它们的相互作用。受试者在4个频率水平（0.9、1.2、1.5和1.8 Hz）上执行4种不同的周期运动任务，即单手左右运动、双手同相运动、双手反相运动和双手90度异相运动。结果表明，在参与双手协调的神经网络中，可以区分出功能亚回路：辅助运动区、顶叶上皮层（SPS）和丘脑VPL Nc的激活主要与肢体运动的时空复杂性增加相关，表明这些区域参与了高阶运动控制。相比之下，初级运动皮层、扣带运动皮层（CMC）、苍白球和丘脑VLo Ne的激活主要与运动频率相关，表明这些区域在运动执行过程中发挥重要作用。有趣的是，小脑和背侧运动前皮层被确定为对这两个参数的操作做出反应的主要区域，并表现出明显的相互作用效应。因此，这两个区域都是控制双手协调的关键部位。(C) 2004爱思唯尔公司版权所有。
In the present functional magnetic resonance imaging (fMRI) study, we assessed the neural network governing bimanual coordination during manipulations of spatiotemporal complexity and cycling frequency. A parametric analysis was applied to determine the effects of each of both factors as well as their interaction. Subjects performed four different cyclical movement tasks of increasing spatiotemporal complexity (i.e., unimanual left-right hand movements, bimanual in-phase movements, bimanual anti-phase movements, and bimanual 90degrees out-of-phase movements) across four frequency levels (0.9, 1.2, 1.5, and 1.8 Hz). Results showed that, within the network involved in bimanual coordination, functional subcircuits could be distinguished: Activation in the supplementary motor area, superior parietal cortex (SPS), and thalamic VPL Nc was mainly correlated with increasing spatiotemporal complexity of the limb movements, suggesting that these areas are involved in higher-order movement control. By contrast, activation within the primary motor cortex, cingulate motor cortex (CMC), globus pallidus, and thalamic VLo Ne correlated mainly with movement frequency, indicating that these areas play an important role during movement execution. Interestingly, the cerebellum and the dorsal premotor cortex were identified as the principal regions responding to manipulation of both parameters and exhibiting clear interaction effects. Therefore, it is concluded that both areas represent critical sites for the control of bimanual coordination. (C) 2004 Elsevier Inc. All rights reserved.