Demethylation of TNFSF7 contributes to CD70 overexpression in CD4+ T cells from patients with systemic sclerosis
Demethylation of TNFSF7 contributes to CD70 overexpression in CD4+ T cells from patients with systemic sclerosis
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TNFSF7 去甲基化导致系统性硬化症患者 CD4 T 细胞中 CD70 过度表达
DOI：
10.1016/j.clim.2012.01.005
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发表时间：
2012-04-01
影响因子：
8.6
通讯作者：
Lu, QianJin
中科院分区：
文献类型：
--
作者：
Jiang, HongYan;Xiao, Rong;Lu, QianJin
系统性硬化症（SSc）的发病机制尚不清楚。CD70是一种在B T细胞接触过程中与CD27相互作用的B细胞共刺激分子，由于其启动子调节元件在来自以下自身免疫性疾病患者的CD4+ T细胞中的去甲基化而过表达，所述自身免疫性疾病即系统性红斑狼疮（SLE）、亚急性皮肤红斑狼疮（SCLE）和原发性干燥综合征（pSS）。然而，作为一种自身免疫性疾病，SSc患者的CD4+ T细胞是否存在CD70的异常表达和甲基化尚不清楚，本研究旨在探讨SSc患者的CD4+ T细胞是否存在CD70的异常表达和甲基化状态。结果表明，SSc中CD4+ T细胞中CD70高表达，CD70启动子区脱甲基化，提示CD70启动子区脱甲基化参与了SSc中CD4+ T细胞中CD70的高表达，并可能参与了SSc的自身免疫反应。(C)2012 Elsevier Inc. All rights reserved.
The pathogenesis of systemic sclerosis (SSc) is still unclear. CD70, a B cell costimulatory molecule that interacts with CD27 during B T cell contact, is overexpressed due to demethylation of its promoter regulatory elements in CD4+ T cells from patients with the following autoimmune diseases, namely systemic lupus erythematosus (SLE), subacute cutaneous lupus erythematosus (SCLE) and primary Sjogren's syndrome (pSS). However, as an autoimmune disease, it is unknown whether aberrant expression and methylation of CD70 occur in SSc CD4+ T cells.We aimed to investigate whether the aberrant expression and methylation status of CD70 occur in CD4+ T cells from patients with SSc. We found that the CD70 is overexpressed and the CD70 promoter region is demethylated in SSc CD4+ T cells.These findings suggest that demethylation of CD70 promoter region contributes to the overexpression of CD70 in CD4+ T cells and may contribute to autoimmune response in SSc. (C) 2012 Elsevier Inc. All rights reserved.