Phencyclidine injections into the dorsal hippocampus disrupt long- but not short-term memory within a spatial learning task.
Phencyclidine injections into the dorsal hippocampus disrupt long- but not short-term memory within a spatial learning task.
复制标题
向背侧海马注射苯环己哌啶会破坏空间学习任务中的长期记忆，但不会破坏短期记忆。
DOI：
10.1007/bf02246194
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发表时间：
1995
影响因子：
3.4
通讯作者：
Dakis,M
中科院分区：
文献类型：
--
作者：
Kesner,RP;Dakis,M
由于海马可能是苯环己哌啶 (PCP) 作用的主要部位，因此测试了直接注射到海马齿状回的不同剂量的 PCP（1.8、18 或 36 nM）以及 3.6 nM MK-801 或盐水的效果，以获取空间导航任务（旱地版本的水迷宫），使用基于一天内学习和评估短期记忆的范式。基于几天之间学习的长期记忆。结果表明，相对于注射生理盐水或 1.8 nM PCP 的大鼠，注射 18 或 36 nM PCP 或 3.6 nM MK-801 的大鼠在完成任务时受到损害，这是通过在几天之间而非几天内寻找食物位置的移动距离增加来衡量的。在其他实验中，36 nM PCP 或 3.6 nM MK-801 在获得物体辨别任务时没有产生任何缺陷。这表明PCP通过其对齿状回或背侧海马CA1区的NMDA受体的阻断作用介导新空间位置信息的巩固。
Since the hippocampus is likely to be a major site of phencyclidine (PCP) action, the effects of various doses of PCP (1.8, 18 or 36 nM) as well as 3.6 nM MK-801 or saline injected directly into the dentate gyrus of the hippocampus was tested for acquisition of a spatial navigation task (dry land version of a water maze) using a paradigm that assesses short term memory based on learning within a day and long term memory based on learning between days. Results indicated that relative to saline or 1.8 nM PCP injected rats, rats with 18 or 36 nM PCP or 3.6 nM MK-801 injections were impaired in acquisition of the task as measured by increased distances traveled to find the food location between days but not within days. In additional experiments 36 nM PCP or 3.6 nM MK-801 did not produce any deficits in the acquisition of an object discrimination task. It is suggested that PCP through its blocking action of the NMDA receptor in the dentate gyrus or CA1 region of the dorsal hippocampus mediates the consolidation of new spatial location information.