Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors
Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors
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DOI：
10.1016/j.humimm.2008.01.009
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发表时间：
2008-03-01
期刊：
影响因子：
2.7
通讯作者：
Hurley, Carolyn Katovich
中科院分区：
文献类型：
--
作者：
Hou, Lihua;Steiner, Noriko K.;Hurley, Carolyn Katovich
使用基因组测序来表征来自 80 个不相关（主要是白种人）个体的 5 个二域刺激性杀伤细胞免疫球蛋白样受体 (KIR) 位点的大部分编码区。 26% (KIR2DS3) 至 98% (KIR2DS4) 的个体中存在特定基因座。已知等位基因的数量从 1 个（KIR2DS1、KIR2DS5）到 5 个（KIR2DS4）不等。基因座和等位基因的频率与欧洲和亚洲种族人群中的观察结果相似。在 2DS1（*00202、'00302、*005、*006、*007）和 2DS4（*008）位点发现了新的等位基因。 (c) 2008 年美国组织相容性和免疫遗传学学会。由爱思唯尔公司出版。保留所有权利。
Genomic sequencing was used to characterize most of the coding regions of the five two-domain stimulatory killer cell immunoglobulin-like receptor (KIR) loci from 80 unrelated, primarily Caucasian, individuals. Specific Loci were present in from 26% (KIR2DS3) to 98% (KIR2DS4) of individuals. The number of known alleles present varied from one (KIR2DS1, KIR2DS5) to five (KIR2DS4). The frequencies of Loci and alleles were similar to observations made in populations of European and Asian ethnicities. New alleles were found at 2DS1 (*00202, '00302, *005, *006, *007) and 2DS4 (*008) loci. (c) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. ALL rights reserved.