Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review.

Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review.
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DOI:
10.1016/j.ccm.2014.10.002
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发表时间:
2015-03
影响因子:
5.7
通讯作者:
Marras TK
Marras TK
中科院分区:
医学3区
文献类型:
--
作者:
Prevots DR;Marras TK

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基于人口的数据显示,自2000年以来,NTM患病率持续上升。北美和澳大利亚的年流行率为每100 000人3.2-9.8人,一般高于欧洲。来自韩国、日本和台湾的NTM PD研究也表明患病率增加。在非洲和中东,NTM的流行率在疑似结核病例中为4%-15%,在疑似耐多药结核(MDR TB)病例中为18%-20%。M.鸟类复合群(MAC)在北美和东亚占优势,而M. kansasii,M. xenopi和M.在欧洲比较常见。对目前NTM PD流行病学重要的宿主因素包括胸部骨骼异常、类风湿性关节炎和免疫调节药物的使用。家族内的疾病聚集性提示疾病易感性的遗传倾向。温暖、潮湿的环境和高大气蒸气压会增加人口风险。
Population-based data have documented a continued increase in NTM prevalence since 2000. Annual prevalence in North American and Australia ranges from 3.2–9.8 per 100,000, and is generally higher than in Europe. Studies of NTM PD from South Korea, Japan, and Taiwan, also suggest increasing prevalence. In Africa and the Middle East, prevalence of NTM ranges from 4% –15% among suspected TB cases and 18%–20% among suspected multi-drug resistant TB (MDR TB) cases. M. avium complex (MAC) is predominant in North America and East Asia, whereas M. kansasii, M. xenopi, and M. malmoense are more common in Europe. Host factors important to the current epidemiology of NTM PD include thoracic skeletal abnormalities, rheumatoid arthritis, and use of immunomodulatory drugs. Clustering of disease within families suggests a heritable genetic predisposition to disease susceptibility. Warm, humid environments with high atmospheric vapor pressure contribute to population risk.
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