Increased VWF antigen levels and decreased ADAMTS13 activity in preeclampsia
Increased VWF antigen levels and decreased ADAMTS13 activity in preeclampsia
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DOI：
10.1179/1607845412y.0000000070
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发表时间：
2013-07-01
期刊：
影响因子：
1.9
通讯作者：
Goda, Hosam
中科院分区：
文献类型：
--
作者：
Aref, Salah;Goda, Hosam
本研究旨在探讨子痫前期患者血管性血友病因子(VWF)抗原水平及其蛋白水解酶ADAMTS13活性。这项研究包括10名未怀孕妇女、50名正常妊娠妇女和110名同期妊娠的先兆子痫(PE)妇女。用FRETS-VWF 73法测定所有受试者的血浆ADAMTS13活性，用免疫比浊法测定VWF抗原水平。PE组血浆ADAMTS13活性明显低于正常妊娠组和非妊娠组(P均<0.01)。而PE组血浆VWF抗原和VWF RCO显著高于正常妊娠组和非妊娠组(P均<0.01)。结论：血浆ADAMTS13降低和VWF升高可能在PE的发病机制中起一定作用。
This study aimed to assess the von Willebrand factor (VWF) antigen levels and its proteolytic enzyme ADAMTS13 activity in preeclampsia. The study includes 10 non-pregnant women, 50 normal pregnancy, and 110 preeclamptic (PE) women at the same period of pregnancy. For all studied groups plasma ADAMTS13 activities were determined with the FRETs-VWF 73 assay, while VWF antigen levels with an immunoturbometric assay. The plasma ADAMTS13 activity was significantly reduced in PE as compared with normal pregnancy and non-pregnant women (P < 0.01 for both). In contrast, plasma VWF antigen and VWF RCO were significantly elevated in PE, as compared with normal pregnancy group as well as non-pregnant women (P < 0.01 for both). In conclusion, reduction of plasma ADAMTS13 and elevation in VWF might have a role in the pathogenesis of PE.