Conversion of concept-specific decision confidence into integrative introspection in primates
Conversion of concept-specific decision confidence into integrative introspection in primates
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DOI：
10.1016/j.celrep.2022.110581
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发表时间：
2022-03-29
期刊：
影响因子：
8.8
通讯作者：
Miyashita，Yasushi
中科院分区：
文献类型：
--
作者：
Miyamoto，Kentaro;Setsuie，Rieko;Miyashita，Yasushi
基于整合不确定证据的自省对于抽象思维和想象未来情景至关重要。然而，它是未知的如何从不同的概念的多个来源的信心读出集成，特别是考虑到概念之间的关系。在这项研究中，猴子进行赌博的基础上估计他们的表现在前面的记忆决定。我们发现，决策后下注的反应时间越长，由正面干扰造成的损害就越减轻。这表明存在一个耗时的补偿性代谢过程。我们发现后下顶叶（pIPL）作为其候选者，其本身并不编码下注（即，只是高赌注或低赌注），但当猴子成功地选择了基于记忆决策表现的最佳赌注选项时，猴子变得更加活跃。此后，pIPL提示背侧前扣带皮层携带所选择的下注选项。我们的研究结果表明pIPL在元认知概念整合中的作用。
Introspection based on the integration of uncertain evidence is critical for acting upon abstract thinking and imagining future scenarios. However, it is unknown how confidence read-outs from multiple sources of different concepts are integrated, especially considering the relationships among the concepts. In this study, monkeys performed wagering based on an estimation of their performance in a preceding mnemonic decision. We found that the longer the response times for post-decision wagering, the more relieved the impairments having been caused by frontal disruption. This suggests the existence of a time-consuming compensatory metacognitive process. We found posterior inferior parietal lobe (pIPL) as its candidate, which was not coding the wagering per se (i.e., just high bet or low bet), but became more active when monkeys successfully chose the optimal bet option based on mnemonic decision performance. Thereafter, the pIPL prompts dorsal anterior cingulate cortex to carry the chosen wagering option. Our findings suggest a role for the pIPL in metacognitive concept integration.