Weight gain and adipose tissue metabolism after smoking cessation in women
Weight gain and adipose tissue metabolism after smoking cessation in women
复制标题
DOI：
10.1038/sj.ijo.0801716
复制
发表时间：
2001-09-01
影响因子：
4.9
通讯作者：
Goldberg, AP
中科院分区：
文献类型：
--
作者：
Ferrara, CM;Kumar, M;Goldberg, AP
背景：吸烟会增加患心血管疾病的风险，是一种重要的可预防的死亡和疾病原因。戒烟的一个主要障碍是体重增加。了解导致体重增加的机制可以最大限度地提高长期戒烟的成功率。我们假设戒烟与脂肪组织脂蛋白脂肪酶（AT-LPL）活性的增加和/或脂肪分解的减少有关，这两个代谢因素决定了脂肪储存和脂肪利用之间的平衡，从而影响体重增加的倾向。材料和方法：10名绝经前妇女(37.1 +/- 6.2 y, 31.7 +/- 6.4 kg/m（2)体重指数（BMI），平均+/- sd）参加了为期4周的戒烟计划。在基线和戒烟4周后测量体重、腰围和臀围、脂肪细胞代谢和静息代谢率。结果：在开始干预的10名妇女中，有5名成功完成了戒烟干预。戒烟4周后，体重显著增加（95.1 +/- 13.9-97.7 +/- 14.4 kg, P < 0.05），腰臀围和静息能量消耗无变化。所有女性臀肌AT-LPL活性显著增加2.8倍（1.65 +/- 1.30-4.72 +/- 3.34 nmol/g/min, P < 0.05）。5名妇女中有4名腹部AT-LPL活性增加，但没有达到统计学意义（1.14 +/- 0.88-3.50 +/- 3.76 nmol/g/min, P = 0.14）。体重增加与臀AT-LPL活性升高相关（r = 0.89, P < 0.05），与臀AT-LPL基线活性升高相关（r = 0.86, P = 0.06）。臀部或腹部脂肪库的基础或刺激脂肪分解没有变化。结论：这些结果表明，戒烟与体重的显著增加以及脂肪细胞代谢的变化，特别是AT-LPL活性的增加有关。LPL活动的增加可能导致与戒烟相关的体重增加。
BACKGROUND: Cigarette smoking increases the risk of cardiovascular disease, and is an important preventable cause of death and illness. One major deterrent to smoking cessation is a gain in body weight. Understanding the mechanisms that contribute to this weight gain may maximize the success of long-term smoking cessation. We hypothesized that smoking cessation is associated with an increase in adipose tissue lipoprotein lipase (AT-LPL) activity and/or a decrease in lipolysis, two metabolic factors that determine the balance between fat storage and fat utilization, and thus affect the propensity for weight gain.MATERIALS AND METHODS: Ten premenopausal women (37.1 +/- 6.2 y, 31.7 +/- 6.4 kg/m(2) body mass index (BMI), mean +/- s.d.) participated in a 4 week smoking cessation program. Measurements of body weight, waist and hip circumferences, adipose cell metabolism and resting metabolic rate were obtained at baseline and after 4 weeks of smoking cessation.RESULTS: Of the 10 women who began the intervention, five successfully completed the smoking cessation intervention. After 4 weeks of smoking cessation, there were significant increases in body weight (95.1 +/- 13.9-97.7 +/- 14.4 kg, P < 0.05), with no change in waist and hip circumferences or resting energy expenditure. Gluteal AT-LPL activity significantly increased in all women by 2.8-fold (1.65 +/- 1.30-4.72 +/- 3.34 nmol/g/min, P < 0.05). Abdominal AT-LPL activity increased in four out of the five women, but did not reach statistical significance (1.14 +/- 0.88-3.50 +/- 3.76 nmol/g/min, P = 0.14). The increase in body weight correlated with the increase in gluteal AT-LPL activity (r = 0.89, P < 0.05), as well as the baseline activity of gluteal AT-LPL (r = 0.86, P = 0.06). There were no changes in basal or stimulated lipolysis in the gluteal or abdominal fat depots.CONCLUSIONS: These results suggest that smoking cessation is associated with significant increases in body weight, as well as changes in adipose cell metabolism, in particular increases in AT-LPL activity. This increase in LPL activity may contribute to the increase in body weight associated with smoking cessation.