High skeletal muscle adenylate cyclase in malignant hyperthermia.
High skeletal muscle adenylate cyclase in malignant hyperthermia.
复制标题
恶性高热中骨骼肌腺苷酸环化酶升高。
DOI：
10.1172/jci110355
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Wood,DS
中科院分区：
文献类型：
--
作者：
Willner,JH;Cerri,CG;Wood,DS
恶性高热发生在患有几种先天性肌病的人类中，通常是对全身麻醉的反应。通常，发展这种综合征的个体缺乏肌肉疾病的症状，并且他们的肌肉缺乏特定的病理变化。这种肌病的生化标志物以前还没有，我们发现腺苷酸环化酶的活性和环AMP的含量在骨骼肌中异常高。蛋白磷酸化的二次修饰可以解释所观察到的磷酸化酶激活和肌浆网功能异常。
Malignant hyperthermia occurs in humans with several congenital myopathies, usually in response to general anesthesia. Commonly, individuals who develop this syndrome lack symptoms of muscle disease, and their muscle lacks specific pathological changes. A biochemical marker for this myopathy has not previously been available; we found activity of adenylate cyclase and content of cyclic AMP to be abnormally high in skeletal muscle. Secondary modification of protein phosphorylation could explain observed abnormalities of phosphorylase activation and sarcoplasmic reticulum function.