Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: A prospective cohort study of trucking company employees in Kenya
Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: A prospective cohort study of trucking company employees in Kenya
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DOI：
10.1086/314884
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发表时间：
1999-08-01
影响因子：
6.4
通讯作者：
Kreiss, JK
中科院分区：
文献类型：
--
作者：
Lavreys, L;Rakwar, JP;Kreiss, JK
为了确定包皮环切术状态对获得人类免疫缺陷病毒（HIV）1型和其他性传播疾病的影响，在肯尼亚蒙巴萨对746名HIV-1血清阴性的卡车运输公司员工进行了一项前瞻性队列研究。在随访过程中，43名男性获得了HIV-1抗体，年发病率为3.0%。生殖器溃疡和尿道炎的年发病率分别为4.2%和15.5%。在多变量分析中，在控制人口统计学和行为变量后，未行包皮环切术是HIV-1感染（风险率比[HRR] = 4.0; 95%置信区间[CI]，1.9-8.3）和生殖器溃疡疾病（HRR = 2.5; 95% CI，1.1-5.3）的独立危险因素。包皮环切术状态对尿道感染和生殖器疣的获得没有影响。在这个卡车运输公司员工的前瞻性队列中，未行包皮环切术的状态与HIV-1感染和生殖器溃疡疾病的风险增加相关，并且在控制潜在混杂因素后，这些影响仍然存在。
To determine the effect of circumcision status on acquisition of human immunodeficiency virus (HIV) type 1 and other sexually transmitted diseases, a prospective cohort study of 746 HIV-1-seronegative trucking company employees was conducted in Mombasa, Kenya. During the course of follow-up, 43 men acquired HIV-1 antibodies, yielding an annual incidence of 3.0%. The annual incidences of genital ulcers and urethritis were 4.2% and 15.5%, respectively. In multivariate analysis, after controlling for demographic and behavioral variables, uncircumcised status was an independent risk factor for HIV-1 infection (hazard rate ratio [HRR] = 4.0; 95% confidence interval [CI], 1.9-8.3) and genital ulcer disease (HRR = 2.5; 95% CI, 1.1-5.3). Circumcision status had no effect on the acquisition of urethral infections and genital warts. In this prospective cohort of trucking company employees, uncircumcised status was associated with increased risk of HIV-1 infection and genital ulcer disease, and these effects remained after controlling for potential confounders.