Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
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DOI：
10.1371/journal.pone.0086254
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Felber BK
中科院分区：
文献类型：
--
作者：
Kulkarni V;Valentin A;Rosati M;Alicea C;Singh AK;Jalah R;Broderick KE;Sardesai NY;Le Gall S;Mothe B;Brander C;Rolland M;Mullins JI;Pavlakis GN;Felber BK
HIV sequence diversity and potential decoy epitopes are hurdles in the development of an effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24gag elements (CE) induced robust immunity in all 10 vaccinated macaques, whereas full-length gag DNA vaccination elicited responses to these conserved elements in only 5 of 11 animals, targeting fewer CE per animal. Importantly, boosting CE-primed macaques with DNA expressing full-length p55gag increased both magnitude of CE responses and breadth of Gag immunity, demonstrating alteration of the hierarchy of epitope recognition in the presence of pre-existing CE-specific responses. Inclusion of a conserved element immunogen provides a novel and effective strategy to broaden responses against highly diverse pathogens by avoiding decoy epitopes, while focusing responses to critical viral elements for which few escape pathways exist.
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影响因子：
3.7
作者：
Almeida RR;Rosa DS;Ribeiro SP;Santana VC;Kallás EG;Sidney J;Sette A;Kalil J;Cunha-Neto E
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Cunha-Neto E
影响因子：
82.9
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Korber, Bette T.
影响因子：
30.5
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Brander, C
影响因子：
4.8
作者：
Jalah, Rashmi;Rosati, Margherita;Felber, Barbara K.
通讯作者：
Felber, Barbara K.
DOI：
10.1073/pnas.0408773102
发表时间：
2005-03-22
影响因子：
11.1
作者：
Betts, MR;Exley, B;Ferrari, G
通讯作者：
Ferrari, G