A PTX/nitinol stent combination with temperature-responsive phase-change 1-hexadecanol for magnetocaloric drug delivery: Magnetocaloric drug release and esophagus tissue penetration
A PTX/nitinol stent combination with temperature-responsive phase-change 1-hexadecanol for magnetocaloric drug delivery: Magnetocaloric drug release and esophagus tissue penetration
复制标题
用于磁热药物输送的 PTX/镍钛合金支架与温度响应相变 1-十六烷醇的组合：磁热药物释放和食道组织渗透
DOI：
10.1016/j.biomaterials.2017.10.040
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发表时间：
2018-01-01
期刊：
影响因子：
14
通讯作者：
Guo, Shengrong
中科院分区：
文献类型：
--
作者：
Jin, Zhu;Wu, Keqin;Guo, Shengrong
抗肿瘤药物/食管支架组合可以姑息性缓解恶性食管狭窄并对癌症进行局部化疗。将该组合物置于恶性狭窄的食管部分后，控制药物释放并促进药物渗透到深层组织中对于有效治疗癌症至关重要。本研究首先设计并制备了一种新型抗肿瘤药物/食管支架组合：磁热镍钛合金支架，其涂层为双层膜，双层膜由一层作为药物阻挡层的乙烯-醋酸乙烯酯共聚物（伊娃）和一层含有10%紫杉醇（PTX）和30%温敏相变脂肪醇（1-十四醇、1-十六醇或1-十八醇）的伊娃组成。研究了药物的释放和对兔食管壁的渗透。结果发现，在0.1kW功率的交变电磁场下，组合物被加热到43 ℃，PTX从组合物中释放更快和更多，并且从组合物中穿透的食管组织或其深层肌肉组织中的PTX量远高于没有交变电磁场的情况。病理学数据表明，即使在交变电磁场下，该组合物放置在兔食管中后也具有生物相容性和安全性。总体而言，PTX可通过磁热释放，并从PTX/镍钛合金支架组合中有效穿透至食管壁。(C)2017爱思唯尔有限公司版权所有
An antitumor drug/esophagus stent combination can palliatively relieve malignant esophageal stricture and exert local chemotherapy to cancer. It is vital for effective treatment of cancer to control drug release and facilitate drug penetration into deep tissue after the combination is placed in the malignant strictured esophagus part. In this study, we firstly designed and prepared a novel antitumor drug/esophagus stent combination: a magnetocaloric nitinol stent coated with a bilayered film that consisted of one ethylene-vinyl acetate copolymer (EVA) layer as drug blocking layer and one EVA layer containing 10% paclitaxel (PTX) and 30% temperature sensitive phase-change fatty alcohol (1-tetradecanol, 1-hexadecanol or 1-octadecanol). The drug release and penetration into rabbit esophagus wall from the combination were investigated. It was found that, under an alternating electromagnetic field at a power of 0.1 kW, the combination was heated to 43 degrees C, the PTX was faster and more released from the combination, as well as the amount of PTX in esophagus tissue or its deep muscle tissue penetrated from the combination was much higher than that without alternating electromagnetic field. The pathological data showed that the combination was biocompatible and safe after placement in rabbit esophagus even under an alternating electromagnetic field. Overall, the PTX could be magnetocalorically released and effectively penetrated into esophagus wall from the PTX/nitinol stent combination. (C) 2017 Elsevier Ltd. All rights reserved.