Cingulate fasciculus integrity disruption in schizophrenia: A magnetic resonance diffusion tensor imaging study
Cingulate fasciculus integrity disruption in schizophrenia: A magnetic resonance diffusion tensor imaging study
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DOI：
10.1016/s0006-3223(03)00419-0
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发表时间：
2003-12-01
影响因子：
10.6
通讯作者：
Shenton, ME
中科院分区：
文献类型：
--
作者：
Kubicki, M;Westin, CF;Shenton, ME
背景资料：有证据表明，边缘系统网络完整性的破坏，特别是扣带回（CG），可能在精神分裂症的病理生理学中发挥作用;然而，扣带束（CB），既提供CG的输入又提供CG的输出的白色物质束，以及边缘系统中最突出的白色物质纤维束，还没有评估精神分裂症使用扩散张量成像（DTI）的新技术。方法：我们使用线扫描DTI评估了16例男性精神分裂症患者和18例男性对照者的CB扩散，这些患者的年龄，父母的社会经济地位，和惯用手我们获得了整个大脑4毫米厚的冠状切片。分数各向异性（FA）的地图生成量化扩散内的左，右CB的8个切片，包括CB的中央部分。结果：结果显示组间差异，双边，在面积和平均FA CB，患者表现出较小的面积和各向异性比对照组。对于患者，左CB下降与注意力和工作记忆的措施，评估由威斯康星州卡片分类Test.Conclusions：这些数据提供了强有力的证据CB中断精神分裂症，这可能与疾病相关的注意力和工作记忆异常。
Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), the white matter tract furnishing both input and output to CG, and the most prominent white matter fiber tract in the limbic system, has not been evaluated in schizophrenia using the new technology of diffusion tensor imaging (DTI).Methods: We used line scan DTI to evaluate diffusion in the CB in 16 male schizophrenia patients and 18 male control subjects, group-matched for age, parental socioeconomic status, and handedness. We acquired 4-mm-thick coronal slices through the entire brain. Maps of fractional anisotropy (FA) were generated to quantify diffusion within the left and right CB on eight slices that included the central portion of the CB.Results: Results showed group differences, bilaterally, in area and mean FA for CB, where patients showed smaller area and less anisotropy than controls. For patients, decreased left CB correlated significantly with attention and working memory measures as assessed by the Wisconsin Card Sorting Test.Conclusions: These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities.