Association of cord blood cytokine levels with wheezy infants in the first year of life
Association of cord blood cytokine levels with wheezy infants in the first year of life
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DOI：
10.1111/j.1399-3038.2008.00783.x
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发表时间：
2009-05-01
影响因子：
4.4
通讯作者：
Morikawa, Akihiro
中科院分区：
文献类型：
--
作者：
Tadaki, Hiromi;Arakawa, Hirokazu;Morikawa, Akihiro
由于产前环境可能影响特应性免疫反应的发展，因此脐带血细胞因子的产生可能是喘息的一个重要预测因素。我们在一个前瞻性的出生队列中研究了脐带血细胞因子，并在1岁时对喘息婴儿的结局进行了密切监测。对269例儿童的脐带血血清样本进行了白细胞介素（IL）-1 β、-2、-4至-8、-10、-12（p70）、-13和-17、干扰素-γ、肿瘤坏死因子-α、粒细胞-巨噬细胞集落刺激因子、粒细胞集落刺激因子（G-CSF）、单核细胞趋化蛋白-1和巨噬细胞炎性蛋白-1 β的检测。分析了家族史、产前和围产期因素、脐带血细胞因子浓度和喘息婴儿结局（喘息超过两次）之间的关系。在269名儿童的脐带血血清中，高水平的IL-6、IL-8和G-CSF浓度与剖腹产之间存在相关性。1年的数据来自213名婴儿，包括33名喘息婴儿。喘息的风险与胎龄、出生体重、剖宫产和母亲湿疹有关，但与妊娠期间细菌/病毒感染、母亲哮喘、母亲吸烟或父亲病史无关。高水平的脐带血IL-8浓度与1岁时喘息性婴儿的结局有显著相关性（p = 0.025）。多因素Logistic回归分析显示，出生体重[OR = 0.998，95% CI = 0.997-1.000]和母亲湿疹[OR = 5.356，95% CI = 1.340-21.41]是婴幼儿喘息的重要预测因素，其他因素无统计学意义。出生体重、胎龄和母亲病史是婴儿出生后第一年发生喘息的重要危险因素。剖宫产影响了几种脐带血细胞因子的产生，IL-8可能是1年后喘息复发的预测因子。
As antenatal environment may influence the development of atopy-predisposing immune response, cord blood cytokine productions may be an important predictor for wheezing. We investigated cord blood cytokines in a prospective birth cohort, intensively monitored for wheezy infant outcome at 1 yr. Cord blood serum samples from 269 children were assayed for interleukin (IL)-1 beta, -2, -4 to -8, -10, -12 (p70), -13, and -17, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor (G-CSF), monocyte chemotactic protein-1, and macrophage inflammatory protein-1 beta. Associations between family histories, antenatal and perinatal factors, cord blood cytokine concentrations, and wheezy infant outcomes (wheezing more than two times) were analyzed. In cord blood sera from 269 children, there were associations between high levels of IL-6, -8 and G-CSF concentrations, and cesarean section. Data at 1 yr were obtained from 213 infants, including 33 wheezy infants. Risk of wheezing was related to gestational age, birth weight, cesarean section, and maternal eczema, but not to bacterial/viral infection during pregnancy, maternal asthma, maternal smoking, or paternal history. High level of cord blood IL-8 concentration had a significant association with wheezy infant outcomes at 1 yr (p = 0.025). By using multivariate logistic regression analysis, birth weight [odds ratio(OR) = 0.998, 95% confidence interval (CI) = 0.997-1.000] and maternal eczema (OR = 5.356, 95% CI = 1.340-21.41), but no other factors, were significant predictors of wheezy infants. Birth weight, gestational age, and maternal history were important risk factors for wheezing in the first year of life. Several cord blood cytokine productions were influenced by cesarean section, and IL-8 may be a predictor for recurrent wheezing at 1 yr.