Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
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DOI：
10.1038/ni1240
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发表时间：
2005-09-01
影响因子：
30.5
通讯作者：
Luster, AD
中科院分区：
文献类型：
--
作者：
Bromley, SK;Thomas, SY;Luster, AD
T细胞在外周组织和淋巴室之间的循环对免疫监视和宿主防御至关重要。然而，决定T细胞是留在外周组织还是回到循环中的因素尚不确定。在这里，我们证明了趋化因子受体CCR7是决定T细胞从外周组织中退出的关键信号。CCR7(-)和CCR7(+)效应T细胞均进入哮喘小鼠肺内，在CCR7(-)T细胞积聚的同时，CCR7(+)T细胞继续向传入淋巴迁移。将CCR7(+)和CCR7(-)T细胞直接送入呼吸道，发现只有CCR7(+)T细胞离开肺进入引流淋巴结。我们的研究为T细胞从外周组织中退出奠定了分子基础。
T cell circulation between peripheral tissues and the lymphoid compartment is critical for immunosurveillance and host defense. However, the factors that determine whether T cells remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate that the chemokine receptor CCR7 is a critical signal that determines T cell exit from peripheral tissue. Both CCR7 (-) and CCR7(+) effector T cells entered mouse asthmatic lung and while CCR7 (-) T cells accumulated, CCR7(+) T cells continued to migrate into afferent lymph. Delivery of both CCR7(+) and CCR7(-) T cells directly into the airways showed that only CCR7(+) T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues.