REVERSIBLE BINDING AND INHIBITION OF CATALASE BY NITRIC-OXIDE
REVERSIBLE BINDING AND INHIBITION OF CATALASE BY NITRIC-OXIDE
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DOI：
10.1111/j.1432-1033.1995.tb20798.x
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发表时间：
1995-08-15
期刊：
影响因子：
--
通讯作者：
BROWN, GC
中科院分区：
文献类型：
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作者：
BROWN, GC
研究了一氧化氮（NO）、H2O2和过氧化氢酶之间的相互作用。过氧化氢酶的存在下，H2O2没有引起可检测的故障NO，但没有引起NO故障的过氧化氢酶的存在下。过氧化氢酶结合NO，NO快速可逆地抑制过氧化氢酶，Ki为0.18 μ M。这些结果对NO细胞毒性的意义进行了讨论。
The interactions between nitric oxide (NO), H2O2, and catalase were investigated. H2O2 did not cause detectable breakdown of NO in the absence of catalase, but did cause NO breakdown in the presence of catalase. Catalase bound NO, and NO rapidly and reversibly inhibited catalase with a K-i of 0.18 mu M. The significance of these results for NO cytotoxicity is discussed.