The Dietary Flavonoid Quercetin Increases VO2max and Endurance Capacity
The Dietary Flavonoid Quercetin Increases VO2max and Endurance Capacity
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DOI：
10.1123/ijsnem.20.1.56
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发表时间：
2010-02-01
影响因子：
2.5
通讯作者：
Murphy, E. Angela
中科院分区：
文献类型：
--
作者：
Davis, J. Mark;Carlstedt, Catherine J.;Murphy, E. Angela
槲皮素是一种存在于多种食用植物中的天然多酚类黄酮物质，已在体外和动物研究中显示出具有广泛的健康和性能益处，这是由生物特性（包括抗氧化剂和抗炎活性）以及增加线粒体生物合成的能力的组合产生的。然而，人们对这些影响知之甚少，特别是在运动表现方面。作者确定了摄入槲皮素是否会增强健康但未经训练的参与者在长时间运动中的最大有氧能力和延迟疲劳。12名志愿者被随机分配到两种治疗中的一种：（a）500 mg槲皮素，每天两次，溶于富含维生素的汤中，或（B）无区别的安慰剂（汤）。确定了基线最大摄氧量和骑自行车至疲劳的时间。采用随机化、双盲、安慰剂对照、交叉研究设计，进行为期7天的治疗。治疗后测定最大摄氧量和疲劳骑行时间。7天的槲皮素喂养与最大摄氧量的适度增加（与安慰剂相比为3.9%; p <0.05）相关，沿着疲劳骑行时间的显著增加（13.2%）（p <0.05）。这些数据表明，在未经训练的参与者中，只需7天的槲皮素补充就可以增加耐力，而无需运动训练。槲皮素的这些益处可能对增强运动和军事表现具有重要意义。没有运动训练的健身明显增加，可能会产生超出性能增强的影响，以促进健康和预防疾病。
Quercetin, a natural polyphenolic flavonoid substance present in a variety of food plants, has been shown in vitro and in animal studies to have widespread health and performance benefits resulting from a combination of biological properties, including antioxidant and anti-inflammatory activity, as well as the ability to increase mitochondrial biogenesis. Little is known about these effects in humans, however, especially with respect to exercise performance. The authors determined whether quercetin ingestion would enhance maximal aerobic capacity and delay fatigue during prolonged exercise in healthy but untrained participants. Twelve volunteers were randomly assigned to 1 of 2 treatments: (a) 500 mg of quercetin twice daily dissolved in vitamin-enriched Tang or (b) a nondistinguishable placebo (Tang). Baseline VO2max and bike-ride times to fatigue were established. Treatments were administered for a period of 7 days using a randomized, double-blind, placebo-controlled, crossover study design. After treatment both VO2max and ride time to fatigue were determined. Seven days of quercetin feedings were associated with a modest increase in VO2max (3.9% vs. placebo; p < .05) along with a substantial (13.2%) increase in ride time to fatigue (p < .05). These data suggest that as little as 7 days of quercetin supplementation can increase endurance without exercise training in untrained participants. These benefits of quercetin may have important implications for enhancement of athletic and military performance. This apparent increase in fitness without exercise training may have implications beyond that of performance enhancement to health promotion and disease prevention.