Immunodeficiency in the 1990s.
Immunodeficiency in the 1990s.
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20世纪90年代的免疫缺陷。
DOI：
10.1097/00006454-199108000-00009
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
H. Hill
中科院分区：
文献类型：
--
作者：
S. Shyur;H. Hill
对于复发或严重感染的患者，应提高潜在免疫缺陷的可能性。虽然这种疾病很罕见（原发性免疫缺陷的发病率约为1/10 000，无症状伊加缺乏症的发病率为20/10 000** 除外），但这种疾病的早期诊断可以预防许多严重后果，包括慢性肺病、局部化脓性感染和严重败血症的发展。此外，指示病例的及时诊断可以为随后的遗传咨询、携带者检测、产前诊断和及时的免疫治疗提供机会。由于这些原因，执业儿科医生保持高度怀疑免疫缺陷的指数和了解用于评估免疫系统的技术是很重要的。
In patients with recurrent or severe infections the possibility of an underlying immunodeficiency should be raised. Although such disorders are rare (the incidence of primary immunodeficiency is approximately 1/10 000 with the exception of asymptomatic IgA deficiency which occurs with an incidence of 20/10 000**), the early diagnosis of such disease could prevent a number of serious consequences including the development of chronic lung disease, local suppurative infections and overwhelming sepsis. Moreover prompt diagnosis of an index case could provide the chance for subsequent genetic counseling, carrier detection, prenatal diagnosis and prompt institution of immunotherapy. For these reasons it is important for practicing pediatricians to maintain a high index of suspicion of immunodeficiency and to be knowledge-able about the techniques used in evaluating the im-mune system.