Optimization of singlet oxygen production from photosensitizer-incorporated, medically relevant hydrogels.
Optimization of singlet oxygen production from photosensitizer-incorporated, medically relevant hydrogels.
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优化含有光敏剂的医学相关水凝胶的单线态氧生产。
DOI：
10.1002/jbm.b.33562
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发表时间：
2017-02
期刊：
影响因子：
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通讯作者：
Gorman SP
中科院分区：
文献类型：
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作者：
De Baróid ÁT;McCoy CP;Craig RA;Carson L;Andrews GP;Jones DS;Gorman SP
光动力疗法和光动力抗菌化学疗法被广泛使用，但尽管如此，能量密度，照射波长和单线态氧（1 O2）的生产之间的关系知之甚少。为了在医学相关材料中建立这些因素之间的关系，在不同的照明功率和时间下，应用总能量为50.48 J/cm 2的通量对四（4-N-甲基吡啶基）卟啉（TMPyP）-掺入的甲基丙烯酸2-羟乙酯：甲基丙烯酸甲酯：甲基丙烯酸（HEMA：MMA：MAA）共聚物产生的1 O2的影响。使用蒽-9，10-二丙酸二钠盐（ADPA），使用最近描述的方法表征1 O2产生。使用两个光源，一个白色LED阵列和一个白色卤素源，发现当施加相同的功率（超过500 - 600 nm）和时间条件时，LED阵列产生的1 O2比卤素源少。重要的是，它表明，最长的波长Q带（590 nm）是主要负责1 O2的产生，并增加功率和时间和单线态氧的生产之间存在线性关系。© 2015 Wiley Periodicals，Inc. J Biomed Mater Res Part B：Appl Biomater，105 B：320-326，2017。
Photodynamic therapy and photodynamic antimicrobial chemotherapy are widely used, but despite this, the relationships between fluence, wavelength of irradiation and singlet oxygen (1O2) production are poorly understood. To establish the relationships between these factors in medically relevant materials, the effect of fluence on 1O2 production from a tetrakis(4‐N‐methylpyridyl)porphyrin (TMPyP)‐incorporated 2‐hydroxyethyl methacrylate: methyl methacrylate: methacrylic acid (HEMA: MMA:MAA) copolymer, a total energy of 50.48 J/cm2, was applied at varying illumination power, and times. 1O2 production was characterized using anthracene‐9,10‐dipropionic acid, disodium salt (ADPA) using a recently described method. Using two light sources, a white LED array and a white halogen source, the LED array was found to produce less 1O2 than the halogen source when the same power (over 500 − 600 nm) and time conditions were applied. Importantly, it showed that the longest wavelength Q band (590 nm) is primarily responsible for 1O2 generation, and that a linear relationship exists between increasing power and time and the production of singlet oxygen. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 320–326, 2017.