The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence.
The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence.
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DOI：
10.1210/edrv-13-2-281
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发表时间：
1992-05
影响因子：
20.3
通讯作者：
J. R. Kerrigan;A. Rogol
中科院分区：
文献类型：
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作者：
J. R. Kerrigan;A. Rogol
I. GH分泌的生理调节最近一直是一个活跃的研究课题。特别是，性类固醇激素和GH的相互作用和独立功能已经成为基础科学和临床竞技场中大量研究的主题。基于多项临床研究的结果，已经观察到在性腺类固醇激素存在下GH分泌被放大。在男性和女性青春期期间，正常、性早熟或性早熟诱导的自发循环GH水平通过调幅现象增加。使用最近可用的数学建模技术，它已经可以证明，这种增加的机制是通过性类固醇激素诱导的内源性GH生产率的放大，没有明显改变的频率分泌发作或激素半衰期。我们打算回顾一下对这种关系的理解.
I. Introduction PHYSIOLOGIC regulation of GH secretion has been an active subject of investigation recently. In particular, the interaction with, and independent functions of, the sex steroid hormones and GH have been the subjects of a large number of studies, both in the basic sciences and in the clinical arena. Based on the results of multiple clinical studies, it has been observed that GH secretion is amplified in the presence of gonadal steroid hormones. During the course of male and female puberty, either normal, precocious, or pharmacologically induced, spontaneously circulating GH levels increase via an amplitude- modulated phenomenon. Using recently available mathematical modeling techniques, it has been possible to demonstrate that the mechanism of this increase is via sex steroid hormone-induced amplification of endogenous GH production rate, without demonstrable alterations of the frequency of secretory episodes or of hormone half-life. We intend to review what is understood about this relation...