Biodistribution and Dosimetry of Free 211At, 125I- and 131I- in Rats
Biodistribution and Dosimetry of Free 211At, 125I- and 131I- in Rats
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DOI：
10.1089/cbr.2013.1483
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发表时间：
2013-11-01
影响因子：
3.4
通讯作者：
Forssell-Aronsson, Eva
中科院分区：
文献类型：
--
作者：
Spetz, Johan;Rudqvist, Nils;Forssell-Aronsson, Eva
I-131广泛用于临床治疗，I-125和I-131以及越来越多的At-211经常用于实验研究。在使用含有这些放射性核素的放射性药物时，了解这些放射性核素的生物分布和剂量测定对于确定潜在的风险器官非常重要。本研究的目的是研究I-125（-）、I-131（-）和游离At-211在大鼠体内的生物分布，并确定各器官和组织的吸收剂量。雄性Sprague道利大鼠同时注射0.1-0.3MBq I-125（-）和0.1-0.3MBq I-131（-），或0.05-0.2MBq At-211，于注射后1小时至7天处死。测定各器官和组织中的放射性和放射性浓度，计算平均吸收剂量。I-125（-）的生物分布与I-131（-）相似，但游离At-211的生物分布与I-125（-）和I-131（-）不同。放射性碘在甲状腺中的活度浓度高于At-211，而在所有甲状腺外组织中的活度浓度低于At-211。甲状腺单位注射放射性的平均吸收剂量最高。I-131对甲状腺的吸收剂量最高，At-211对所有其他研究组织的吸收剂量最高。
I-131 is widely used for therapy in the clinic and I-125 and I-131, and increasingly At-211, are often used in experimental studies. It is important to know the biodistribution and dosimetry for these radionuclides to determine potential risk organs when using radiopharmaceuticals containing these radionuclides. The purpose of this study was to investigate the biodistribution of I-125(-), I-131(-), and free At-211 in rats and to determine absorbed doses to various organs and tissues. Male Sprague Dawley rats were injected simultaneously with 0.1-0.3MBq I-125(-) and 0.1-0.3MBq I-131(-), or 0.05-0.2MBq At-211 and sacrificed 1 hour to 7 days after injection. The activities and activity concentrations in organs and tissues were determined and mean absorbed doses were calculated. The biodistribution of I-125(-) was similar to that of I-131(-) but the biodistribution of free At-211 was different compared to I-125(-) and I-131(-). The activity concentration of radioiodine was higher compared with At-211 in the thyroid and lower in all extrathyroidal tissues. The mean absorbed dose per unit injected activity was highest to the thyroid. I-131 gave the highest absorbed dose to the thyroid, and At-211 gave the highest absorbed dose to all other tissues studied.