BETA-STRUCTURES OF ALTERNATING POLYPEPTIDES AND THEIR POSSIBLE PREBIOTIC SIGNIFICANCE
BETA-STRUCTURES OF ALTERNATING POLYPEPTIDES AND THEIR POSSIBLE PREBIOTIC SIGNIFICANCE
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DOI：
10.1038/256383a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
ORGEL, LE
中科院分区：
文献类型：
--
作者：
BRACK, A;ORGEL, LE
对在益生元条件下形成的最常见氨基酸的调查表明，最早的遗传编码形式可能具有特定的多肽，具有形成稳定β-片结构的强烈倾向。聚（Val-Lys），像其他多肽一样，疏水和亲水残基交替存在，倾向于形成β结构。我们表明，具有疏水的内部和亲水的外部双层可能存在于水溶液中。
A survey of the commonest amino acids formed in prebiotic conditions suggests that the earliest form of genetic coding may have specified polypeptides with a strong tendency to form stable β-sheet structures. Poly(Val-Lys), like other polypeptides in which hydro-phobic and hydrophilic residues alternate, tends to form β structures. We show that bilayers with a hydrophobic interior and a hydrophilic exterior may be present in aqueous solution.