Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine.

Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine.
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DOI:
10.1186/s13059-014-0453-8
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发表时间:
2014-08-27
期刊:
影响因子:
12.3
通讯作者:
Swanton C
Swanton C
中科院分区:
生物学1区
文献类型:
--
作者:
Hiley C;de Bruin EC;McGranahan N;Swanton C

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The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
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