Synthesis of carbohydrate-conjugated dT analogues using 'Click chemistry'
Synthesis of carbohydrate-conjugated dT analogues using 'Click chemistry'
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DOI：
10.1055/s-2007-983881
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发表时间：
2007-10-01
影响因子：
2.6
通讯作者：
Ju, Yong
中科院分区：
文献类型：
--
作者：
Jin, Xuanye;Yang, Ruchun;Ju, Yong
利用Sonogashira偶联法和点击化学法合成了一种新型的呋喃并[2，3-d]嘧啶核苷。在随后的脱保护的4-甲苯甲酰基和乙酰基与催化甲醇钠在甲醇中，呋喃并[2，3-d]嘧啶重排为开放的酮型结构。它们的结构都是在光谱学的基础上确定的。
A new type furo[2,3-d]pyrimidine nucleoside conjugated with various carbohydrates was synthesized using Sonogashira coupling and 'click chemistry'. In the subsequent deprotection of the 4-toluoyl and acetyl groups with catalytic sodium methoxide in methanol, the furo[2,3-d]pyrimidine rearranged to an opened ketone-type structure. Their structures were confirmed on the basis of spectroscopy.