The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.
The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.
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DOI：
10.1016/j.gde.2015.03.002
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发表时间：
2015-06
影响因子：
4
通讯作者：
Goessling W
中科院分区：
文献类型：
--
作者：
Cox AG;Goessling W
肝脏是一个重要的器官，在新陈代谢，消化和营养储存中起着关键作用。斑马鱼作为研究肝脏发育和再生过程中肝脏生长调控途径的模型系统，已经取得了很大的进展。与其他脊椎动物相比，斑马鱼具有独特的优势，包括细胞分辨率的体内成像以及大规模化学和遗传筛选的能力。本文综述了斑马鱼肝脏发育过程中调控肝脏生长的细胞和分子机制。我们还强调了新出现的证据，即肝损伤后发育途径被重新激活，以促进再生。最后，我们讨论了斑马鱼如何改变药物发现的努力，并使药物的刺激肝脏生长，并提供肝损伤的临床前模型中的肝保护的鉴定，以确定新的治疗方法来治疗肝脏疾病的最终目标。
The liver is an essential organ that plays a pivotal role in metabolism, digestion and nutrient storage. Major efforts have been made to develop zebrafish (Danio rerio) as a model system to study the pathways regulating hepatic growth during liver development and regeneration. Zebrafish offer unique advantages over other vertebrates including in vivo imaging at cellular resolution and the capacity for large-scale chemical and genetic screens. Here, we review the cellular and molecular mechanisms that regulate hepatic growth during liver development in zebrafish. We also highlight emerging evidence that developmental pathways are reactivated following liver injury to facilitate regeneration. Finally, we discuss how zebrafish have transformed drug discovery efforts and enabled the identification of drugs that stimulate hepatic growth and provide hepatoprotection in pre-clinical models of liver injury, with the ultimate goal of identifying novel therapeutic approaches to treat liver disease.