Gestational obesity accentuates obesity in obesity-prone progeny
Gestational obesity accentuates obesity in obesity-prone progeny
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DOI：
10.1152/ajpregu.1998.275.4.r1374
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发表时间：
1998-10-01
影响因子：
2.8
通讯作者：
Govek, E
中科院分区：
文献类型：
--
作者：
Levin, BE;Govek, E
母亲肥胖和遗传背景可影响后代肥胖和糖尿病的发展。在这里，我们使用了选择的大鼠品系抵抗（DR）与易感高能量（HE）饮食的饮食诱导肥胖（DIO）的发展来评估这个问题。DR和DIO母鼠饲喂普通饲料或HE饲料4周。DIO HE饮食喂养的大鼠和另外的DR大鼠喂养可口的液体饮食（Ensure）变得比其他组更肥胖和高胰岛素血症。在哺乳期，所有母鼠饲喂各自的饲料，后代从断奶至16周龄饲喂松狮犬。与DR后代相比，DIO darns的所有后代体重增加更多，腹膜后脂肪垫更重，瘦素水平更高，但更肥胖的DIO HE母鼠的后代比DIO Chow后代有更重的脂肪垫和更高的葡萄糖水平。HE饮食4周后，所有DIO后代的体重增加更多，总脂肪蓄积量更重，胰岛素和瘦素水平高于DR后代。DIO HE母鼠的后代也比DIO Chow后代增加了更多的体重，具有更重的脂肪库和更高的瘦素水平。因此，母亲肥胖和高胰岛素血症与那些已经遗传倾向于肥胖的后代肥胖增加有关。
Maternal obesity and genetic background can affect the development of obesity and diabetes in offspring. Here we used selected strains of rats resistant (DR) vs. susceptible to development of diet-induced obesity (DIO) on high-energy (HE) diets to assess this issue. DR and DIO dams were fed either Chow or HE diet for 4 wk. DIO HE diet-fed darns and additional DR rats fed a palatable liquid diet (Ensure) became more obese and hyperinsulinemic than the other groups. During lactation, all dams were fed their respective diets, and offspring were fed Chow from weaning to 16 wk of age. All offspring of DIO darns gained more weight and had heavier retroperitoneal fat pads and higher leptin levels than DR progeny, but offspring of the more obese DIO HE dams had heavier fat pads and higher glucose levels than DIO Chow offspring. After 4 wk on HE diet, all DIO offspring gained more weight and had heavier total adipose depots and higher insulin and leptin levels than DR offspring. Offspring of DIO HE dams also gained more weight and had heavier fat depots and higher leptin levels than DIO Chow offspring. Therefore maternal obesity and hyperinsulinemia were associated with increased obesity in those offspring already genetically predisposed to become obese.