The browning of white adipose tissue and body weight loss in primary hyperparathyroidism
The browning of white adipose tissue and body weight loss in primary hyperparathyroidism
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原发性甲状旁腺功能亢进症的白色脂肪组织褐变和体重减轻
DOI：
10.1016/j.ebiom.2018.11.057
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发表时间：
2019-02-01
期刊：
影响因子：
11.1
通讯作者：
Liu, Jian-min
中科院分区：
文献类型：
--
作者：
He, Yang;Liu, Rui-xin;Liu, Jian-min
背景：在肺癌小鼠模型中，甲状旁腺激素相关蛋白（PTHrP）引发白色脂肪组织（WAT）布朗宁和恶病质。方法：采用腺相关病毒（Ad-A）注射方法，建立Pth基因过表达的PHPT小鼠模型，观察其WAT布朗宁和体重变化。本文对496例PHPT患者进行了甲状旁腺素（PTH）与体重关系的研究。20 PHPT和60对照组的脂肪布朗宁活动与PET/CT scanning.Findings：血浆PTH升高触发脂肪组织布朗宁，导致能量消耗增加，脂肪含量减少，并最终降低PHPT小鼠的体重。高循环PTH水平与低体重相关（β =-0.048，P =. 0003）独立于PHPT患者的肾功能、血清钙、磷和白蛋白水平。PHPT患者表现出较高的可检测的棕色/米色脂肪组织的患病率（20%vs3.3%，P = 0.03）和增加的布朗宁活动（颈部脂肪的SUV为0.77 vs0.49，P = 0.02）与对照subjects.Interpretation：升高的血清PTH驱动WAT布朗宁程序，这部分地导致PHPT小鼠和患者的体重减轻。这些结果为进一步认识PTH的新的病理作用提供了新的思路，对了解PHPT的代谢变化具有重要意义。(c)2018由Elsevier B. V.出版
Background: Parathyroid hormone related protein (PTHrP) triggers white adipose tissue (WAT) browning and cachexia in lung cancer mouse models. It remains unknown whether excessive PTH secretion affects WAT browning and to what extent it contributes to body weight change in primary hyperparathyroidism (PHPT).Methods: Using the adeno-associated virus injection, Pth gene over-expressed mice mimicking PHPT were firstly established to observe their WAT browning and body weight alteration. The association between PTH and body weight was investigated in 496 PHPT patients. The adipose browning activities of 20 PHPT and 60 control subjects were measured with PET/CT scanning.Findings: Elevated plasma PTH triggered adipose tissue browning, leading to increased energy expenditure, reduced fat content, and finally decreased body weight in PHPT mice. Higher circulating PTH levels were associated with lower body weight (beta = -0.048, P =. 0003) independent of renal function, serumcalcium, phosphorus, and albumin levels in PHPT patients. PHPT patients exhibited both higher prevalence of detectable brown/beige adipose tissue (20% vs 3.3%, P = .03) and increased browning activities (SUV in cervical adipose was 0.77 vs 0.49, P = .02) compared with control subjects.Interpretation: Elevated serum PTH drove WAT browning program, which contributed in part to body weight loss in both PHPT mice and patients. These results give insights into the novel pathological effect of PTH and are of importance in understanding the metabolic changes of PHPT. (c) 2018 Published by Elsevier B.V.