ROLE OF SUPRACHIASMATIC NUCLEI IN GENERATION OF CIRCADIAN-RHYTHMS IN GOLDEN-HAMSTER, MESOCRICETUS-AURATUS
ROLE OF SUPRACHIASMATIC NUCLEI IN GENERATION OF CIRCADIAN-RHYTHMS IN GOLDEN-HAMSTER, MESOCRICETUS-AURATUS
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DOI：
10.1007/bf00611819
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
RUSAK, B
中科院分区：
文献类型：
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作者：
RUSAK, B
在雄性金黄地鼠M。金色的。破坏视交叉上核（SCN）的下丘脑和伴随中断的视网膜-下丘脑束（RHT）修改或消除夹带照明周期。这种病变也阻止了正常活动和饮酒的昼夜节律的产生。一些病变仓鼠产生双峰（约12小时）和三峰（约8小时）的活动模式在恒定的条件下。其他病变的仓鼠似乎是在恒定的条件下，低振幅（约8小时）的节奏，功率谱分析显示，在许多这些仓鼠的记录。许多受损仓鼠的记录显示出几个活动组件，彼此分离，并从照明周期和自由独立运行了许多周期。这些和其他功能的活动记录表明，在仓鼠的活动节律控制的振荡单位的相互耦合产生的功能正常的昼夜节律的复杂。SCN显然负责维持这些振荡器之间的正常耦合，从而产生昼夜行为节律。在某些仓鼠中SCN破坏后残留夹带的存在表明，除了RHT之外的视觉通路可以在有限程度上介导光对昼夜节律系统的影响。
Neural mechanisms involved in the generation and entrainment of circadian rhythms of behavior were studied in male golden hamsters M. auratus. Destruction of the suprachiasmatic nuclei (SCN) of the hypothalamus and accompanying interruption of the retino-hypothalamic tract (RHT) modified or eliminated entrainment to lighting cycles. Such lesions also prevented the generation of normal circadian rhythms of activity and drinking. Some lesioned hamsters generated bimodal (circa 12 h) and trimodal (circa 8 h) activity patterns in constant conditions. Other lesioned hamsters appeared to be arrhythmic under constant conditions; power spectral analysis revealed low amplitude (circa 8 h) rhythms in the records of many of these hamsters. The records of many lesioned hamsters showed several activity components that dissociated from each other and from the illumination cycle and free ran independently for many cycles. These and other features of the activity records indicated that activity rhythms in hamsters were controlled by a complex of oscillatory units whose mutual coupling produced the features of normal circadian rhythmicity. The SCN are apparently responsible for the maintenance of normal coupling among these oscillators and thus for the generation of circadian behavioral rhythmicity. The presence of residual entrainment after SCN destruction in some hamsters showed that visual pathways other than the RHT can to a limited extent mediate light effects on the circadian system.