800 nm near-infrared light-excitable intense green-emitting Li(Gd,Y)F4: Yb,Er-based core/shell/shell upconversion nanophosphors for efficient liver cancer cell imaging
800 nm near-infrared light-excitable intense green-emitting Li(Gd,Y)F4: Yb,Er-based core/shell/shell upconversion nanophosphors for efficient liver cancer cell imaging
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DOI：
10.1016/j.matdes.2020.108941
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发表时间：
2020-10-01
影响因子：
8.4
通讯作者：
Jang, Ho Seong
中科院分区：
文献类型：
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作者：
Choi, Jung Eun;Kim, Hee-Kwon;Jang, Ho Seong
在这项研究中，报道了一种新的800nm可激发和高强度绿色发光的非nay (Gd) f -4基核/壳/壳（CSS）上转换纳米荧光粉（UCNPs）。合成了白石晶结构的Li(Gd，Y)F-4:Yb，Er核心UCNPs，随后形成Nd3+掺杂的活性壳层和惰性壳层，并将新型Li(Gd，Y)F-4:Yb,Er /LiYF4:Nd，Yb/LiGdF4 CSS UCNPs应用于肝癌细胞靶向上转换发光成像。x射线衍射和电子能量损失谱证实了单方相白钨矿结构CSS UCNPs的成功合成。由于在核心上形成了活性壳层和惰性壳层，CSS UCNPs在800和980 nm的激发下都显示出明亮的绿光。特别是，合成的CSS UCNPs在800 nm激发下具有0.15%的绝对上转换量子产率。为了靶向肝癌细胞，合成了游离胺和聚乙二醇（PEG）引入的甘草次酸（GA） （GA-PEG- nh2），并将GA-PEG- nh2与CSS UCNPs偶联，表面用聚丙烯酸钠盐修饰。利用ga - peg - nh2共轭的CSS UCNPs和808 nm近红外激光对HepG2肝癌细胞进行了成像，成功实现了肝癌细胞的体内成像。(c) 2020作者。Elsevier Ltd.出版。这是一篇基于CC BY-NC-ND许可（http://creativecommons.org/licenses/by-nc-nd/4.0/）的开放获取文章。
In this study, novel 800 nm-excitable and highly intense green-emitting non-NaY(Gd)F-4-based core/shell/shell (CSS) upconversion nanophosphors (UCNPs) are reported. Scheelite-structured Li(Gd,Y)F-4:Yb,Er core UCNPs are synthesized, followed by the formation of a Nd3+-doped active shell and inert shell, and the novel Li(Gd,Y) F-4:Yb,Er/LiYF4:Nd,Yb/LiGdF4 CSS UCNPs are applied to liver cancer cell-targeted upconversion luminescence imaging. X-ray diffraction and electron energy loss spectroscopy confirm that single tetragonal phase scheelite-structured CSS UCNPs are successfully synthesized. Because of the formation of the active shell and inert shell on the core, CSS UCNPs display bright green light under both 800 and 980 nm excitations. In particular, the synthesized CSS UCNPs exhibit a high absolute upconversion quantum yield of 0.15% under 800 nm excitation. For liver cancer cell targeting, free amine and poly(ethylene glycol) (PEG)-introduced glycyrrhetinic acid (GA) (GA-PEG-NH2) is synthesized, and the GA-PEG-NH2 is conjugated with the CSS UCNPs, whose surface was modified with poly(acrylic acid sodium salt). HepG2 liver cancer cells are imaged with the GA-PEG-NH2-conjugated CSS UCNPs and an 808 nm near-infrared laser, and in vivo liver cancer cell imaging is successfully conducted. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).