Associations of Nut Intakes with Incident Sporadic Colorectal Adenoma: A Pooled Case-Control Study.
Associations of Nut Intakes with Incident Sporadic Colorectal Adenoma: A Pooled Case-Control Study.
复制标题
坚果摄入量与散发性结直肠腺瘤事件的关联：一项汇总病例对照研究。
DOI：
10.1080/01635581.2018.1521440
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Bostick,RoberdM
中科院分区：
文献类型：
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作者：
Yin,Xin;Bostick,RoberdM
导读：食用含有多种抗癌成分的坚果与结直肠癌（CRC）呈负相关，特别是在女性中，但尚未研究其与结直肠癌腺瘤（大多数CRC的直接前兆）的关系。方法：我们收集了3项病例对照研究的数据，这些研究涉及偶发性散发性结直肠腺瘤（n= 785例，2107例对照），使用食物频率问卷评估饮食摄入量，并使用多变量无条件logistic回归分析数据。结果：在男性和女性中，对于那些每周食用0.5-1.5份、2.0-5.5份和≥6份坚果产品的人，相对于不食用坚果的人，总坚果产品（所有坚果和花生酱组合）摄入量的多变量调整比值比（OR）和95%置信区间（CI）分别为0.81（0.58,1.12）、0.86（0.61,1.23）和0.93（0.65,1.31）。然而，在女性中，相应的or和95% ci分别为0.62（0.40,0.97）、0.57（0.35,0.94）和0.78（0.48,1.25）。结论：这些结果表明，适度食用坚果可能与结直肠腺瘤的风险降低有关，主要是在女性中。
Introduction:Consumption of nuts, which contain multiple anti-carcinogenic components, has been inversely associated with colorectal cancer (CRC), particularly among women, but has not been investigated in relation to colorectal adenoma, the immediate precursor to most CRCs.Methods:We pooled data from three case-control studies of incident, sporadic colorectal adenoma (n= 785 cases, 2107 controls) in which dietary intakes were assessed using food frequency questionnaires, and analyzed the data using multivariable unconditional logistic regression.Results:Among men and women combined, the multivariable-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association of total nut product (all nuts and peanut butter combined) intakes, for those who consumed 0.5–1.5, 2.0–5.5, and ≥6 servings/week relative to no nut consumption were 0.81 (0.58, 1.12), 0.86 (0.61, 1.23), and 0.93 (0.65, 1.31), respectively. However, among women, the corresponding ORs and 95% CIs were 0.62 (0.40, 0.97), 0.57 (0.35, 0.94), and 0.78 (0.48, 1.25), respectively.Conclusions:These results suggest that moderate nut consumption may be associated with lower risk for colorectal adenoma, primarily among women.