The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: A comparison with tianeptine
The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: A comparison with tianeptine
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DOI：
10.1016/j.biopsych.2004.02.029
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发表时间：
2004-06-15
影响因子：
10.6
通讯作者：
LeDoux, JE
中科院分区：
文献类型：
--
作者：
Burghardt, NS;Sullivan, GM;LeDoux, JE
背景：选择性5-羟色胺再摄取抑制剂(SSRI)可有效治疗多种恐惧或焦虑症。尽管它们在给药后几个小时内抑制了5-羟色胺的重新摄取，但治疗效果只有在几周后才会出现改善。在这项研究中，我们使用恐惧条件反射开始了解急性和慢性SSRI治疗可能不同地影响特征明确的恐惧回路。我们评估了SSRI西酞普兰急性和慢性治疗对听觉恐惧条件反射获得的影响。为了进一步了解5-羟色胺在调节恐惧回路中的作用，我们将这些作用与急性和长期服用抗抑郁药替尼普汀的效果进行了比较。结果：我们发现，急性服用SSRI西酞普兰促进了获得，而慢性治疗减少了听觉恐惧条件反射的获得。结论：西酞普兰的研究结果与SSRI治疗焦虑症患者的临床疗效一致，焦虑障碍患者的焦虑在治疗早期往往会增加，治疗几周后焦虑会减少。这些发现还表明，听觉恐惧条件反射可以作为一种有用的工具，用来理解5-羟色胺能药物的短期和长期抗抑郁治疗效果的差异。
Background: Selective serotonin reuptake inhibitors (SSRIs) are efficacious in the treatment of a variety of fear or anxiety disorders. Although they inhibit the reuptake of serotonin within hours of administration, therapeutic improvement only occurs after several weeks. In this study, we used fear conditioning to begin to understand bow acute and chronic SSRI treatment might differentially affect well-characterized fear circuits.Methods. We evaluated the effects of acute and chronic treatment with the SSRI citalopram on the acquisition of auditory fear conditioning. To further understand the role of serotonin in modulating fear circuits, we compared these effects with those of acute and chronic administration of the antidepressant tianeptine, a purported serotonin reuptake enhancer.Results: We found that acute administration of the SSRI citalopram enhanced acquisition, whereas chronic treatment reduced the acquisition of auditory fear conditioning. In comparison, treatment with tianeptine had no effect acutely but also reduced the acquisition of tone conditioning when administered chronically.Conclusions: Our findings with citalopram are consistent with the clinical effects of SSRI treatment seen in patients with anxiety disorders, in which anxiety is often increased during early stages of treatment and decreased after several weeks of treatment. The findings also indicate that auditory fear conditioning can be a useful tool in understanding differences in the effects of short-term and long-term antidepressant treatment with serotonergic medications.