Remotely actuated shape memory effect of electrospun composite nanofibers
Remotely actuated shape memory effect of electrospun composite nanofibers
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电纺复合纳米纤维的远程驱动形状记忆效应
DOI：
10.1016/j.actbio.2011.12.006
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发表时间：
2012-03-01
影响因子：
9.7
通讯作者：
Zhou, Shaobing
中科院分区：
文献类型：
--
作者：
Gong, Tao;Li, Wenbing;Zhou, Shaobing
以化学交联聚己内酯（c-PCL）为基体，多壁碳纳米管（MWNTs）为增强填料，Fe 3 O 4纳米粒子为磁响应源，采用静电纺丝法制备了一类可生物降解的聚合物复合纳米纤维。复合纤维显示出优异的形状记忆效应，由热水和交变磁场触发。还定量测定了磁性纳米颗粒通过磁场中的磁滞损耗在PCL基质中产生的热量。负载Fe 3 O 4的MWNT复合纳米粒子（1）通过自由基反应在MWNTs表面接枝马来酸酐（MA），再通过酯化反应用β-环糊精（β-CD）共价修饰MWNTs;（2）以β-CD为沉积位点，采用静电自组装法将Fe ~（2+）和Fe ~（3+）离子共沉淀到β-CD功能化的MWNTs表面，制备了Fe_3 O_4 @CD-M复合纳米粒子。还从培养的成骨细胞群体进行阿利兰测定以评价细胞毒性。结果表明，静电纺丝复合纤维具有良好的生物相容性，可应用于生物医学领域。(C)2011 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
One class of biodegradable polymer composite nanofibers was fabricated with an electrospinning process using chemically cross-linked poly(epsilon-caprolactone) (c-PCL) as the matrix and multiwalled carbon nanotubes (MWNTs) as the reinforced filler coated with Fe3O4 nanoparticles as a magnetism responsive source. The composite fibers showed an excellent shape memory effect, triggered both by hot water and by an alternating magnetic field. The heat in the PCL matrix generated from magnetic nanoparticles via hysteresis loss in the magnetic field was also determined quantitatively. The Fe3O4-loaded MWNT composite nanoparticles (Fe3O4@CD-M) were synthesized through two steps: (1) the raw MWNTs were firstly functionalized by grafting maleic anhydride (MA) on their surface through a free radical reaction and later covalently modified by beta-cyclodextrin (beta-CD) through an esterification reaction; (2) Fe3O4@CD-M composite nanoparticles were prepared by chemical co-precipitation of Fe2+ and Fe3+ ions on the surface of the beta-CD functionalized MWNTs with an electrostatic self-assembly approach using beta-CD as the depositional locus. Alamar blue assay was also performed from culturing osteoblast populations to evaluate the cytotoxicity. The result showed that the electrospun composite fibers possessed good biocompatibility and could be applied in biomedical fields. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.