Sequence-dependent DNA structure
Sequence-dependent DNA structure
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DOI：
10.1002/bies.950180212
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发表时间：
1996-02-01
期刊：
影响因子：
4
通讯作者：
Hunter, CA
中科院分区：
文献类型：
--
作者：
Hunter, CA
DNA的三维结构微妙地依赖于它的序列，而这种特性被调节基因表达的蛋白质用来定位它们的靶序列。尽管在序列和DNA结构之间的关系上已经积累了大量的实验数据，但我们仍然没有完全理解这些性质的分子基础，也不能从给定的序列预测三维结构。我们一直在使用计算机建模来解决这些问题。我们的一些结果和理解的关键序列的生物学作用的影响进行了讨论。
The three-dimensional structure of DNA depends subtly on its sequence, and this property is used by the proteins that regulate gene expression to locate their target sequences. Despite the large body of experimental data that has been accumulated on the relationship between sequence and DNA structure, we still do not fully understand the molecular basis for these properties, nor can we predict a three-dimensional structure from a given sequence. We have been using computer modelling to tackle these problems. Some of our results and the implications for understanding the biological role of key sequences are discussed here.