Acute physical dependence in man: effects of naloxone after brief morphine exposure.
Acute physical dependence in man: effects of naloxone after brief morphine exposure.
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发表时间：
1988
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通讯作者：
Warren K. Bickel;M. Stitzer;I. Liebson;G. Bigelow
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作者：
Warren K. Bickel;M. Stitzer;I. Liebson;G. Bigelow
本研究评估了i.m.急性i. m.注射吗啡（0、1、3、5.6、10和17 mg）。纳洛酮逆转残留吗啡引起的呼吸抑制、瞳孔缩小和药物“高”的主观报告。“此外，纳洛酮会诱发阿片类药物戒断的体征和症状。“不良”药物作用和特定阿片类戒断症状的主观报告测量值随着吗啡预处理剂量的增加而增加，戒断症状的主观评估也是如此。打哈欠是最突出的观察到的体征，而打哈欠和易怒是最一致报告的主观症状。在纳洛酮给药后15 min内观察到戒断效应峰值。这项研究的结果证实了以前的报告，急性身体依赖的人，并通过证明吗啡剂量反应函数扩展这些发现。
This study assessed the effects of i.m. naloxone (10 mg) 6 hr after acute i.m. injections of morphine (0, 1, 3, 5.6, 10 and 17 mg). Naloxone reversed residual morphine-produced respiratory depression, miosis and subjective reports of drug "high." In addition, naloxone precipitated signs and symptoms characteristic of opioid withdrawal. Subjective report measures of "bad" drug effects and specific opioid withdrawal symptoms increased as a function of morphine pretreatment dose, as did observer-rated signs of withdrawal. Yawning was the most prominent observed sign, whereas yawning and irritability were the most consistently reported subjective symptoms. Peak withdrawal effects were seen within 15 min post-naloxone. The results of this study confirm previous reports of acute physical dependence in man and extend those findings by demonstrating a morphine dose-response function.