HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure
HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure
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HLA-Dw2：人体对短豚草花粉过敏原 Ra5 的免疫反应的遗传标记。
DOI：
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发表时间：
1982
影响因子：
15.3
通讯作者：
W. Bias
中科院分区：
文献类型：
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作者：
D. Marsh;S. H. Hsu;M. Roebber;E. Ehrlich;L. Freidhoff;D. Meyers;M. Pollard;W. Bias
使用超纯短豚草花粉过敏原 Ra5（5,000 mol wt）研究两组白人受试者（总计 447 人）的人类白细胞抗原（HLA）类型与对 Ra5 的 IgE 和 IgG 抗体（Ab）反应之间的关系。使用高灵敏度放射免疫测定程序测量血清 IgE 和 IgG Ab，发现两组对 Ra5 的定性反应与 HLA-Dw2 密切相关（P 小于 0.0001）。例如，38 名具有 IgE Ab 的人中有 95% 是 Dw2+，而 139 名豚草过敏者中没有可检测到 Ra5 的 IgE Ab 的人中有 22% 是 Dw2+。在四个独立的多元回归分析中，对 Ra5 的定量 log [IgE Ab] 和 log[IgG Ab] 反应与 Dw2 高度相关（P = 10(- 5) 至 10(-14)），检查两个研究组中 HLA 类型（和其他变量）与 Ab 水平之间的关系。进一步的研究表明，Ra5 反应的主要关联是与 Dw2 而不是 DR2，并且 A3、B7 和 Dw2 的各种组合的关联性不如单独的 Dw2。
Ultra-pure short ragweed pollen allergen Ra5 (5,000 mol wt) was used to investigate the relationship between human leukocyte antigen (HLA) type and IgE and IgG antibody (Ab) responses to Ra5 in two groups of Caucasian subjects, totaling 447 people. Using highly sensitive radioimmunoassay procedures to measure serum IgE and IgG Ab, qualitative responses to Ra5 in both groups were found to be strongly associated with HLA-Dw2 (P less than 0.0001). For example, 95% of 38 people with IgE Ab vs. 22% of 139 ragweed-allergic persons having no detectable IgE Ab to Ra5 were Dw2+. Quantitative log [IgE Ab] and log[IgG Ab] responses to Ra5 were highly correlated with Dw2 (P = 10(- 5) to 10(-14)) in four separate multiple regression analyses, examining the relationship between HLA type (and other variables) and Ab levels in the two study groups. Further studies showed that the primary association of Ra5 response was with Dw2 rather than DR2 and that various combinations of A3, B7, and Dw2 were less strongly associated than Dw2 alone.
类风湿性关节炎患病率高的齐珀瓦印第安亚群的 HLA-DR 特征。
影响因子：
2.7
作者：
Bias,WB;Hsu,SH;Pollard,MK;Harvey,J;Lotze,MT;Arnett,FC;Stevens,MB
通讯作者：
Stevens,MB