Cadmium Is More Toxic on Volume Bone Mineral Density than Tissue Bone Mineral Density
Cadmium Is More Toxic on Volume Bone Mineral Density than Tissue Bone Mineral Density
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DOI：
10.1007/s12011-011-9106-x
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发表时间：
2011-12-01
影响因子：
3.9
通讯作者：
Gu, Shuzhu
中科院分区：
文献类型：
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作者：
Chen, Xiao;Zhu, Guoying;Gu, Shuzhu
有研究表明，镉可导致低面积骨密度，但我们不知道镉对立方骨密度的影响。本研究旨在探讨镉对雄性大鼠体积骨密度（VBMD）和组织骨密度（TBMD）的影响。24只SD雄性大鼠随机分为4组，分别皮下注射氯化镉0、0.1、0.5和1.5mg/kg体重，连续8周。然后，对胫骨近端进行微型计算机断层扫描，并使用microview软件重建感兴趣区域。1.5mg/kg镉染毒组大鼠骨密度（VBMD）显著低于对照组（P < 0.01）。染镉组大鼠骨小梁数目均显著低于对照组（p < 0.05）。1.5mg/kg镉染毒组大鼠骨小梁分离度明显高于对照组（P < 0.01）。镉对TBMD无明显影响。镉可引起骨密度降低，但不引起骨密度降低;镉对骨的影响可能与骨小梁丢失有关，但与骨小梁脱矿无关。
It has been showed that Cd induces low areal bone mineral density, but we do not know the effect of Cd on cubic bone density. This study was aimed to investigate the effects of Cd on volumetric bone mineral density (VBMD) and tissue bone mineral density (TBMD) in male rats. Twenty-four Sprague-Dawley male rats were randomly divided into four groups that were given cadmium chloride by subcutaneous injection at doses of 0, 0.1, 0.5, and 1.5 mg/kg body weight for 8 weeks, respectively. Then, microcomputed tomography scanning was performed on the proximal tibia, and region of interest was reconstructed using microview software. The VBMD, bone volume fraction of rats treated with 1.5 mg Cd/kg, were significantly decreased compared to control (p < 0.01). The trabecular numbers of rats exposed to Cd were all significantly decreased relative to control (p < 0.05). The trabecular separation of rats treated with 1.5 mg Cd/kg was obviously increased compared to control (p < 0.01). However, Cd had no obvious influence on TBMD. Cd induced low VBMD but not TBMD; Cd effect on bone may be related with trabecular bone loss but not with trabecular bone demineralization.