Mechanisms of estrogen signaling and gene expression via GPR30.
Mechanisms of estrogen signaling and gene expression via GPR30.
复制标题
通过GPR30的雌激素信号传导和基因表达的机制。
DOI：
10.1016/j.mce.2009.03.026
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发表时间：
2009-09-24
影响因子：
4.1
通讯作者：
Maggiolini, Marcello
中科院分区：
文献类型：
--
作者：
Prossnitz, Eric R.;Maggiolini, Marcello
The effects of estrogen are widespread throughout the body. Although the classical nuclear estrogen receptors have been known for many years to decades and their primary modes of action as transcriptional regulators is well understood, certain aspects of estrogen biology remain inconsistent with the mechanisms of action of these receptor. More recently, the G protein-coupled receptor, GPR30/GPER, has been suggested to contribute to some of the cellular and physiological effects of estrogen. Not only does GPR30 mediate some of the rapid signal transduction events following cell stimulation, such as calcium mobilization and kinase activation, it also appears to regulate rapid transcriptional activation of genes such as c-fos. Since many cells and tissues co-express classical estrogen receptors and GPR30, there exists great diversity in the possible avenues of synergism and antagonism. In this review, we will provide an overview of GPR30 function, focusing on the rapid signaling events that culminate in the transcriptional activation of certain genes.
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DOI：
10.1016/s0960-0760(01)00190-x
发表时间：
2002-02-01
影响因子：
4.1
作者：
Filardo, EJ
通讯作者：
Filardo, EJ
影响因子：
--
作者：
Filardo, EJ;Quinn, JA;Bland, KI
通讯作者：
Bland, KI
影响因子：
5.8
作者：
Baquedano, Maria Sonia;Saraco, Nora;Belgorosky, Alicia
通讯作者：
Belgorosky, Alicia
影响因子：
4.8
作者：
Ahola, TM;Manninen, T;Ylikomi, T
通讯作者：
Ylikomi, T
DOI：
10.1046/j.1432-1033.2002.02912.x
发表时间：
2002-05-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Ahola, TM;Purmonen, S;Ylikomi, T
通讯作者：
Ylikomi, T