Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography
Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography
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DOI：
10.1364/opex.12.004353
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发表时间：
2004-09-20
期刊：
影响因子：
3.8
通讯作者：
van Leeuwen, TG
中科院分区：
文献类型：
--
作者：
Faber, DJ;van der Meer, FJ;van Leeuwen, TG
从校准后的弱散射组织体模（2-6 mm（-1））中，我们从临床相关的“固定焦点”几何结构中的OCT数据中提取了精确度为0.8 mm（-1）的衰减系数。使用一个单一的散射模型和最近开发的共焦点扩散函数（PSF）的描述的数据进行分析。通过与多次散射模型的定量比较，验证了单次散射模型的有效性，并验证了PSF在校准样品上的使用。现有OCT系统的该模型的实现将是简单的。局部定量测量不同组织的衰减系数可显著提高OCT的临床应用价值。（C）2004年美国光学学会。
From calibrated, weakly scattering tissue phantoms (2-6 mm(-1)), we extract the attenuation coefficient with an accuracy of 0.8 mm(-1) from OCT data in the clinically relevant 'fixed focus' geometry. The data are analyzed using a single scattering model and a recently developed description of the confocal point spread function (PSF). We verify the validity of the single scattering model by a quantitative comparison with a multiple scattering model, and validate the use of the PSF on the calibrated samples. Implementation of this model for existing OCT systems will be straightforward. Localized quantitative measurement of the attenuation coefficient of different tissues can significantly improve the clinical value of OCT. (C) 2004 Optical Society of America.