Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study)
Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study)
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DOI：
10.1016/j.jvc.2015.03.008
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发表时间：
2015-12-01
影响因子：
1.2
通讯作者：
Fuentes, Virginia Luis
中科院分区：
文献类型：
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作者：
Payne, Jessie Rose;Brodbelt, David Charles;Fuentes, Virginia Luis
目的：肥厚性心肌病（HCM）似乎在猫中很常见，根据试点数据，假设患病率为15%。目的是筛选大量表面上健康的成年猫是否患有心脏病，并确定与HCM诊断相关的因素。动物：总共1007只6个月大的健康猫。方法：在这项前瞻性横断面研究中，纳入标准是：表面健康的猫，年龄>= 6个月，可在17个月内从两个收容中心被收容。排除高血压或甲状腺功能亢进的猫。评估体重、身体状况评分、听诊、收缩压和二维超声心动图。二维超声心动图显示左室舒张末期壁厚>= 6mm的猫为HCM。结果：780只猫获得了完整的数据。心脏杂音患病率为40.8%(95%可信区间（CI） 37.3-44.3%)，其中70.4%被认为是功能性杂音。HCM患病率为14.7% (95% CI 12.3-17.4%)，先天性疾病患病率为0.5% (95% CI 0.1-1.3%)，其他心肌病患病率为0.1% （95% CI 0.0-0.7%）。HCM患病率随年龄增长而增加。心脏杂音对HCM的阳性预测值为17.9-42.6%（老年猫较高），阴性预测值为90.2-100%（幼猫较高）。在二元logistic回归模型中，与HCM诊断相关的因素是男性、年龄增加、身体状况评分增加和心脏杂音（特别是III/VI级或更大）。结论：与其他心肌病相比，肥厚性心肌病在表面健康的猫中很常见。心脏杂音也很常见，而且通常是功能性的。(C) 2015 Elsevier B.V.版权所有
Objectives: Hypertrophic cardiomyopathy (HCM) appears to be common in cats and, based on pilot data, a prevalence of 15% has been hypothesized. The objectives were to screen a large population of apparently healthy adult cats for cardiac disease, and identify factors associated with a diagnosis of HCM.Animals: A total of 1007 apparently healthy cats >= 6 months of age.Methods: In this prospective, cross-sectional study, the inclusion criteria were: apparently healthy cats, aged >= 6 months, available for rehoming over a 17-month period from two rehoming centres. Hypertensive or hyperthyroid cats were excluded. Body weight, body condition score, auscultation, systolic blood pressure and two-dimensional (2-D) echocardiography were evaluated. Cats with left ventricular end diastolic wall thickness >= 6 mm on 2-D echocardiography were considered to have HCM.Results: Complete data were obtained in 780 cats. Heart murmur prevalence was 40.8% (95% confidence interval (CI) 37.3-44.3%), 70.4% of which were considered functional. The prevalence of HCM was 14.7% (95% CI 12.3-17.4%), congenital disease 0.5% (95% CI 0.1-1.3%), and other cardiomyopathies 0.1% (95% CI 0.0-0.7%). The HCM prevalence increased with age. The positive predictive value of a heart murmur for indicating HCM was 17.9-42.6% (higher in old cats), and the negative predictive value was 90.2-100% (higher in young cats). The factors associated with a diagnosis of HCM in binary logistic regression models were male sex, increased age, increased body condition score and a heart murmur (particularly grade III/VI or louder).Conclusions: Hypertrophic cardiomyopathy is common in apparently healthy cats, in contrast with other cardiomyopathies. Heart murmurs are also common, and are often functional. (C) 2015 Elsevier B.V. All rights reserved.