Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders.
Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders.
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自闭症谱系中声音刺猬蛋白，脑源性神经营养因子和氧化应激之间的关系。
DOI：
10.1007/s11064-011-0624-x
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发表时间：
2012-02
影响因子：
4.4
通讯作者：
Al-Ayadhi, Laila Y.
中科院分区：
文献类型：
--
作者：
Al-Ayadhi, Laila Y.
The etiology of autism spectrum disorders (ASD) is not well known but oxidative stress has been suggested to play a pathological role. We report here that the serum levels of Sonic hedgehog (SHH) protein and brain-derived neurotrophic factor (BDNF) might be linked to oxidative stress in ASD. By using the whole blood or polymorphonuclear leukocytes, we demonstrated that autistic children produced a significantly higher level of oxygen free radicals (OFR). In addition, we found significantly higher levels of serum SHH protein in children with mild as well as severe form of autism. We also found that the serum level of BDNF was significantly reduced in autistic children with mild form of the disorder but not with severe form of the disorder. Our findings are the first to report a correlation between SHH, BDNF and OFR in autistic children, suggesting a pathological role of oxidative stress and SHH in autism spectrum disorders.
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DOI：
10.1111/j.1460-9568.2005.04317.x
发表时间：
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期刊：
The European journal of neuroscience
影响因子：
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作者：
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DOI：
10.1016/j.pathophys.2006.05.007
发表时间：
2006-08-01
期刊：
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影响因子：
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DOI：
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发表时间：
2005-05-01
影响因子：
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