Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells
Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells
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DOI：
10.4049/jimmunol.1500366
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发表时间：
2015-07-01
影响因子：
4.4
通讯作者：
Yarovinsky, Felix
中科院分区：
文献类型：
--
作者：
Sturge, Carolyn R.;Burger, Elise;Yarovinsky, Felix
中性粒细胞是干扰素-γ的一种新的细胞来源，干扰素-γ是一种关键的细胞因子，介导宿主对细胞内病原体的防御。与淋巴细胞不同，中性粒细胞产生干扰素-γ是不依赖于TLR和IL-12的，与中性粒细胞产生干扰素-γ相关的事件尚不清楚。在这项研究中，我们证明了小鼠中性粒细胞在骨髓早幼粒细胞阶段的谱系发育过程中独立于微生物而表达干扰素-γ。干扰素-γ在中性粒细胞中蓄积，在诱导脱颗粒时释放。中性粒细胞产生干扰素-γ的发育机制在感染前武装了先天免疫细胞，并确保了在中性粒细胞激活时快速释放干扰素-γ的可能性，这是许多微生物感染反应的第一步。
Neutrophils are an emerging cellular source of IFN-gamma, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-gamma by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-gamma production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-gamma during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-gamma accumulates in primary neutrophilic granules and is released upon induction of degranulation. The developmental mechanism of IFN-gamma production in neutrophils arms the innate immune cells prior to infection and assures the potential for rapid release of IFN-gamma upon neutrophil activation, the first step during responses to many microbial infections.