Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus
Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus
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DOI：
10.1097/00001756-200208270-00004
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发表时间：
2002-08-27
期刊：
影响因子：
1.7
通讯作者：
Kim, CJ
中科院分区：
文献类型：
--
作者：
Jang, MH;Shin, MC;Kim, CJ
人们普遍认为，酒精和尼古丁会影响学习能力和记忆功能，尤其是青少年。在本研究中，研究了酒精和尼古丁对幼鼠齿状回细胞增殖和凋亡的影响。结果表明，酒精和尼古丁会抑制细胞增殖。此外，酒精和尼古丁会增加末端脱氧核苷酸转移酶介导的 dUTP 缺口标记 (TUNEL) 阳性细胞的数量。根据本研究的结果，可以表明，与酒精和尼古丁相关的学习和记忆功能障碍可能是由于酒精和尼古丁诱导的新细胞形成抑制和细胞凋亡加速造成的，特别是在青春期。
It is generally accepted that alcohol and nicotine affect learning ability and memory functions, especially in adolescents. In the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. The results show that cell proliferation is suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase the number of terminal deoxynucleotidyl transferase-mediated dUTP nick labeling (TUNEL)-positive cells. Based on the results presented in this study, it can be suggested that alcohol- and nicotine-related impairment in learning and memory functions may be due to alcohol- and nicotine-induced suppression of new cell formation and acceleration of apoptosis, especially during adolescence.