Memory bias and its association with memory function in women with posttraumatic stress disorder
Memory bias and its association with memory function in women with posttraumatic stress disorder
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DOI：
10.1016/j.jad.2018.10.365
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发表时间：
2019-02-15
影响因子：
6.6
通讯作者：
Kim, Yoshiharu
中科院分区：
文献类型：
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作者：
Itoh, Mariko;Hori, Hiroaki;Kim, Yoshiharu
背景：记忆异常是创伤后应激障碍（PTSD）的一个核心特征。有人认为，患有创伤后应激障碍 (PTSD) 的人会表现出记忆偏差；而证据表明这些人的记忆功能较差。我们的目的是检查 PTSD 患者相对于对照组的记忆偏差，并探讨记忆偏差与记忆功能之间的关联。方法：对 46 名患有 DSM-IV PTSD 的女性（其中大多数在人际暴力后患上这种疾病）和 68 名未遭受创伤的健康对照女性进行了研究。记忆偏差是通过使用负面、中性和正面词语的识别记忆任务来评估的。记忆功能通过标准化神经心理学测试组进行评估。通过自我报告措施评估抑郁和焦虑症状。结果：与对照组相比，患者表现出显着更高的负偏差分数（即负面词的正确识别率减去中性词的正确识别率）和较差的记忆功能。负偏差评分与患者较差的记忆功能显着相关。当患者被分为记忆功能较低和正常的患者时，前者的负偏倚明显大于后者的患者和对照组。患我们的研究结果可能有助于深入了解创伤后应激障碍（PTSD）记忆异常的本质。
Background: Memory abnormalities are among a central feature of posttraumatic stress disorder (PTSD). It is suggested that individuals with PTSD exhibit memory bias; while evidence shows poor memory function in these individuals. We aimed to examine memory bias in PTSD patients relative to controls and to explore an association between memory bias and memory function.Methods: Forty-six women with DSM-IV PTSD, most of whom developed the disorder after interpersonal violence, and 68 non-trauma-exposed healthy control women were studied. Memory bias was assessed by a recognition memory task using negative, neutral, and positive words. Memory function was assessed by a standardized neuropsychological test battery. Depression and anxiety symptoms were assessed by self-report measures.Results: Compared to controls, patients showed significantly greater negative bias scores (i.e., correctly recognized rates for negative words minus those for neutral words) and poorer memory function. Negative bias scores were significantly correlated with worse memory function in patients. When patients were divided into those with lower vs. normal memory function, the former patients had significantly greater negative bias than the latter patients and controls. Memory bias scores in patients were not significantly correlated with depression or anxiety symptoms, nor were they significantly different between patients with comorbid major depressive disorder and those without.Limitations: The cross-sectional design and absence of the trauma-exposed non-PTSD group limited our findings.Conclusions: PTSD patients have greater negative memory bias, which can be associated with poorer memory function. Our findings may provide an insight into the nature of memory abnormalities in PTSD.