IGF-I enhances neurite regeneration but is not required for its survival in adult DRG explant
IGF-I enhances neurite regeneration but is not required for its survival in adult DRG explant
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DOI：
10.1097/00001756-199707070-00034
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发表时间：
1997-07-07
期刊：
影响因子：
1.7
通讯作者：
Horie, H
中科院分区：
文献类型：
--
作者：
Akahori, Y;Horie, H
我们阐明了胰岛素样生长因子（IGF）I和II在周围神经再生轴突切断后使用培养的成人DRG外植体无论有或没有相关的神经束的作用。当IGF-I以1-10 nM的浓度应用于无血清培养基中没有相关神经束的DRG外植体时，可以看到从中枢和外周横断神经末梢的神经再生的明显增强。当相同浓度的IGF-I应用于DRG外植体与相关的神经束，这种增强减少在中央网站和增加在周边网站。在这些培养系统中，IGF-I均未影响神经存活。与IGF-I相比，IGF-II对轴突再生没有特异性作用。
WE clarified the roles of insulin-like growth factor (IGF) I and II in peripheral neural regeneration after axotomy using cultured adult DRG explants either with or without associated nerve bundles. When IGF-I was applied at concentrations of 1-10 nM to DRG explants without associated nerve bundles in a serum-free medium, clear enhancement of neural regeneration from both central and peripheral transected nerve terminals was seen. When the same concentrations of IGF-I were applied to DRG explants with associated nerve bundles this enhancement was reduced at central sites and increased at peripheral sites. Neural survival was not affected by IGF-I in any of these culture systems. In comparison with IGF-I, there was no specific effect of IGF-II on neurite regeneration.