Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets
Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets
复制标题
普通狨猴颈脊髓损伤后运动过程中保留的节间协调
DOI：
10.1016/j.bbr.2022.113816
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发表时间：
2022
影响因子：
2.7
通讯作者：
Ushiba Junichi
中科院分区：
文献类型：
--
作者：
Sato Yuta;Kondo Takahiro;Uchida Akito;Sato Kenta;Yoshino-Saito Kimika;Nakamura Masaya;Okano Hideyuki;Ushiba Junichi
包括人类在内的灵长类动物在脊髓部分损伤后可以恢复一定的运动功能，但运动模式与损伤前不同。虽然这些观察有许多改善康复策略的影响，这些机制还没有得到很好的理解。在这项研究中，我们使用了一个常见的绒猴半切脊髓损伤模型，以检查运动模式的时间变化，特别是，左后肢的节段间协调。在左侧单侧颈脊髓半切后，绒猴表现出左前肢和后肢的可检测功能丧失。伤后2周，左前肢负重受限，但左后肢可进行足底步。随后，绒猴的行走能力逐渐恢复，但运动学分析显示，端点轨迹和关节角度运动存在差异。此外，在左后肢的平面协变代表的节段间的协调，随着时间的推移，受伤后保存。先前的研究报道，中风或SCI患者的平面协方差被破坏，平面性的改善与康复后步行能力的恢复相关。在这项研究中，四足绒猴即使在SCI后也能够行走而不会失去平衡;两足和四足步行者的不同平衡需求可能导致平面协变的差异。我们的研究结果表明，平面协变被保存在所有的时间点后，颈椎单侧半切。
It is known that primates including human regain some locomotor function after a partial spinal cord injury, but the locomotor pattern is different from before the injury. Although these observations have many implications for improving rehabilitative strategies, these mechanisms are not well understood. In this study, we used a common marmoset hemisection SCI model to examine temporal changes in locomotor pattern, in particular, intersegmental coordination of left hindlimb. Marmoset showed loss of detectable function in the left forelimb and hindlimb after left unilateral hemisection of cervical spinal cord. At two weeks after injury, weight-bearing of the left forelimb during locomotion was limited, but the left hindlimb was able to plantar step. Then marmosets showed gradual recovery in walking ability, but kinematics analysis showed differences in the endpoint trajectory and joint angle movement. Furthermore, intersegmental coordination in left hindlimb represented by planar covariation was preserved over time after the injury. Previous studies have reported that planar covariance is disrupted in patients with stroke or SCI, and that improvement in planarity correlates with recovery in walking ability after rehabilitation. In this study, quadrupedal marmosets were able to walk without loss of balance even after SCI; the different balance needs of bipedal and quadrupedal walkers may lead to differences in planar covariation. Our results show that planar covariation was preserved at all time points after the cervical unilateral hemisection.