REGULATION OF NUCLEIC ACIDS OF MUSCLES AND ACCESSORY SEX ORGANS OF GUINEA PIGS BY ANDROGENS.
REGULATION OF NUCLEIC ACIDS OF MUSCLES AND ACCESSORY SEX ORGANS OF GUINEA PIGS BY ANDROGENS.
复制标题
雄激素对豚鼠肌肉和附属性器官核酸的调节。
DOI：
10.1210/endo-74-4-635
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发表时间：
1964
期刊：
影响因子：
4.8
通讯作者：
D. Harrison
中科院分区：
文献类型：
--
作者：
C. Kochakian;J. Hill;D. Harrison
雄性豚鼠体重约550g时去势，去势后第21天和220天开始的2个系列实验中，雄激素通过皮下植入颗粒(每个颗粒约15 mg)，间隔长达35天。去势和注射雄激素均不影响大鼠腓肠肌和斜肌的重量、RNA和DNA含量。年龄较大的动物肌肉更重，RNA的比例增加，但总DNA没有变化。在去势的动物中，具有代表性的雄激素反应肌肉--颞肌和咬肌--的RNA水平较低。睾酮在5天内产生RNA的即刻最大值增加，这一点在继续注射雄激素后保持不变，但不会进一步增加。去势延缓了颞肌和咬肌DNA达到成人水平的速度。随着去势时间的延长，这些肌肉的DNA会逐渐增加，达到正常的水平。
Male guinea pigs were castrated at approximately 550 g body weight and androgens were administered by subcutaneous implantation of pellets (approximately 15 mg each) for intervals up to 35 days in 2 series of experiments beginning at 21 and 220 days after castration. The weight, RNA and DNA of the oblique and the gastrocnemius muscles were not changed by either castration or androgen administration. The older animals had heavier muscles with a proportionate increase in RNA but no change in total DNA. The RNA of representative androgenresponsive muscles—temporal and masseter— was lower in the castrated animals. Testosterone produced an immediate maximum increase within 5 days in RNA, which was maintained but was not increased further by continued androgen administration. Castration retarded the attainment of the adult level of the DNA in the temporal and the masseter muscles. Prolongation of castration was accompanied by a very gradual increase in the DNA of these muscles, with an attainment of the normal ...