Correlations between regional brain volumes and memory performance in anoxia
Correlations between regional brain volumes and memory performance in anoxia
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DOI：
10.1080/13803390590949287
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发表时间：
2006-05-01
影响因子：
2.2
通讯作者：
Damasio, H
中科院分区：
文献类型：
--
作者：
Allen, JS;Tranel, D;Damasio, H
本研究旨在探讨缺氧患者的区域脑容量（海马、杏仁核以及大脑、额叶、顶叶、颞叶）与逆行和逆行记忆测试成绩之间的定量关系。我们使用高分辨率MRI测量13例缺氧患者的脑容量。神经心理测试与MRI同时进行。为了控制年龄和性别，使用从87名健康对照参与者中导出的回归方程计算神经解剖体积残差。我们发现患有严重健忘症的缺氧患者的海马体体积比正常人小36%，而轻度或无健忘症患者的海马体体积正常。严重失忆症患者的脑灰质体积明显小于预期。在顺行记忆测试中的表现与海马和区域灰质体积残差显著相关。白质体积（而不是海马体积）与视觉保留测试（一种认知功能的多维测试）的表现有显著的相关性。在逆行记忆测试中，神经解剖测量和表现之间没有显著的相关性。我们的研究结果表明，在顺行性记忆测试中的表现与海马和区域灰质体积残差之间存在很强的定量关系。发现白质体积残差与VRT表现之间的相关性与海马体积无关。鉴于海马体积与总灰质体积残差之间存在很强的相关性，定量的、归一化的总灰质体积测量可以很好地指示缺氧时的临床结果。
This study was aimed at investigating the quantitative relationship between regional brain volumes (hippocampus, amygdala, as well as cerebrum, frontal lobe, parietal lobe, temporal lobe) and performance on anterograde and retrograde memory tests in anoxic patients. We used high-resolution MRI to measure brain volumes in 13 anoxic patients. Neuropsychological testing was conducted contemporaneously with MRI. To control for age and sex, neuroanatomical volume residuals were calculated using regression equations derived from a group of 87 healthy comparison participants. We found that anoxic patients with severe amnesia had hippocampal volumes that were 36% smaller than normal, whereas patients with mild or no amnesia had normal hippocampal volumes. Regional gray matter volumes in severe amnesic anoxics were substantially smaller than expected. Performances on anterograde memory tests were significantly correlated with hippocampal and regional gray matter volume residuals. There was a significant correlation between white matter volume (but not hippocampal volume) and performance on the Visual Retention Test, a multi-dimensional test of cognitive function. There were no significant correlations between neuroanatomical measures and performance on a retrograde memory test. Our results indicate a strong quantitative relationship between performance on anterograde memory tests and hippocampal and regional gray matter volume residuals. Correlations between white matter volume residuals and performance on the VRT were found to be independent of hippocampal volume. Given the strong correlation between hippocampal volume and total gray matter volume residuals, a quantitative, normalized measure of total gray matter volume may provide a good indication of clinical outcome in anoxia.