An RNA binding protein negatively controlling differentiation in fission yeast
An RNA binding protein negatively controlling differentiation in fission yeast
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DOI：
10.1128/mcb.18.8.4488
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发表时间：
1998-08-01
影响因子：
5.3
通讯作者：
Okayama, H
中科院分区：
文献类型：
--
作者：
Tsukahara, K;Yamamoto, H;Okayama, H
裂殖酵母裂殖酵母开始性发育时，饥饿的营养和同时激活交配信息素。我们已经确定了一个新的基因调节这一过程的开始。该基因称为nrd1（+），编码一种典型的RNA结合蛋白，优先结合poly（U）。nrd1（+）的缺失导致细胞在没有营养饥饿的情况下启动性发育。我们已经发现，nrd1（+）的生物学作用是通过抑制Ste 11调节的接合和减数分裂所必需的基因来阻止性发育的开始，直到细胞达到饥饿的临界水平。
The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, called nrd1(+), encodes a typical RNA binding protein that preferentially binds poly(U). Deletion of nrd1(+) causes cells to initiate sexual development without nutrient starvation. We have found that the biological role of nrd1(+) is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.