The vaccinia virus soluble interferon-γ receptor is a homodimer
The vaccinia virus soluble interferon-γ receptor is a homodimer
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DOI：
10.1099/0022-1317-83-3-545
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发表时间：
2002-03-01
影响因子：
3.8
通讯作者：
Smith, GL
中科院分区：
文献类型：
--
作者：
Alcamí, A;Smith, GL
牛痘病毒（VV）干扰素（IFN）-γ受体（IFN-γ R）是一种43 kDa的可溶性糖蛋白，在感染早期由感染细胞分泌。在这里，我们表明，从VV，牛痘病毒和骆驼痘病毒的IFN-γ R天然存在的同源二聚体，而细胞的IFN-γ R二聚体只有在结合的同源二聚体IFN-γ。在不存在配体的情况下，病毒蛋白作为二聚体的存在可以为病毒提供在溶液中有效结合和抑制IFN-γ的优势。
The vaccinia virus (VV) interferon (IFN)-gamma receptor (IFN-gammaR) is a 43 kDa soluble glycoprotein that is secreted from infected cells early during infection. Here we demonstrate that the IFN-gammaR from VV, cowpox virus and camelpox virus exists naturally as a homodimer, whereas the cellular IFN-gammaR dimerizes only upon binding the homodimeric IFN-gamma. The existence of the virus protein as a dimer in the absence of ligand may provide an advantage to the virus in efficient binding and inhibition of IFN-gamma in solution.